The innate immune system and the clearance of apoptotic cells

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: apoptosis;    inflammation;    chemotaxis;    phagocytosis;    immune‐;    modulation;    aging;    inflamm‐;    aging;   

DOI  :  10.1189/jlb.0211095

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Removalofunwanted,effete,ordamagedcellsthroughapoptosis,anactivecelldeathculminatinginphagocyticremovalofcellcorpses,isanimportantprocessthroughouttheimmunesystemindevelopment,control,andhomeostasis.Forexample,neutrophilapoptosisiscentraltotheresolutionofacuteinflammation,whereasautoreactiveandvirus‐infectedcellsaresimilarlydeleted.TheACremovalprocessfunctionsnotonlytoremovecellcorpsesbutfurther,tocontrolinappropriateimmuneresponsessothatACsareremovedinananti‐inflammatorymanner.Such″silent″clearanceismediatedbytheinnateimmunesystemviapolarizedmonocyte/macrophagepopulationsthatusearangeofPRRsandsolublemoleculestopromotebindingandphagocytosisofACs.Additionally,attractivesignalsarereleasedfromdyingcellstorecruitphagocytestositesofdeath.Here,wereviewthemolecularmechanismsassociatedwithinnateimmuneremovalofandresponsestoACsandoutlinehowthesemayimpactontissuehomeostasisandage‐associatedpathology(e.g.,cardiovasculardisease).Furthermore,wediscusshowanaginginnateimmunesystemmaycontributetotheinflammatoryconsequencesofagingandwhythestudyofanagingimmunesystemmaybeausefulpathtoadvancecharacterizationofmechanismsmediatingeffectiveACclearance...

【 授权许可】

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