期刊论文详细信息
Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Blood CD33(+)HLA‐DR(−) myeloid‐derived suppressor cells are increased with age and a history of cancer | |
关键词: aging; elderly; inflammaging; mortality; | |
DOI : 10.1189/jlb.0912461 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
![]() |
【 摘 要 】
Asweage,thecompositionofourperipheralleukocyteschangesdramatically.Manyofthesealterationscontributetothegeneralimmunedysfunctionthatburdenstheelderly,whichinturn,contributestoincreasedsusceptibilitytodisease.MDSCsrepresentaheterogeneouspopulationofimmunosuppressiveleukocytesthatareelevatedintheperipheralbloodofcancerpatients.Giventherelationbetweencancerincidenceandage,thisstudyexaminedthefrequencyofperipheralbloodCD33(+)HLA‐DR(−)MDSCsacrossthreecohorts:healthyadults(19–59yearsold),community‐dwellingseniors(61–76yearsold),andfrailelderly(67–99yearsold).ThisanalysisisthefirsttodemonstratethatMDSCsandspecificallytheCD11b(+)CD15(+)MDSCsubsetareincreasedwithage.ProinflammatorycytokinesthatarerequiredforthedifferentiationofMDSCs(e.g.,TNF‐α,IL‐6,andIL‐1β)weresimilarlyfoundtobeincreasedintheserumofthefrailelderly.Furthermore,theproportionofMDSCsandtheCD11b(+)CD15(+)subsetwerefoundtobeelevatedsignificantlyinelderlydonorswithahistoryofcancer.Thisage‐relatedelevationinthefrequencyofMDSCsmaycontributetotheincreasedcancerincidencethatoccurswithage.FurtherinvestigationintothefunctionalconsequencesofelevatedMDSCswillprovidevaluableinsightintotheprogressionofage‐relatedpathologies...【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201901232462404ZK.pdf | 605KB | ![]() |