Blood CD33(+)HLA‐DR(−) myeloid‐derived suppressor cells are increased with age and a history of cancer

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: aging;    elderly;    inflammaging;    mortality;   

DOI  :  10.1189/jlb.0912461

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Asweage,thecompositionofourperipheralleukocyteschangesdramatically.Manyofthesealterationscontributetothegeneralimmunedysfunctionthatburdenstheelderly,whichinturn,contributestoincreasedsusceptibilitytodisease.MDSCsrepresentaheterogeneouspopulationofimmunosuppressiveleukocytesthatareelevatedintheperipheralbloodofcancerpatients.Giventherelationbetweencancerincidenceandage,thisstudyexaminedthefrequencyofperipheralbloodCD33(+)HLA‐DR(−)MDSCsacrossthreecohorts:healthyadults(19–59yearsold),community‐dwellingseniors(61–76yearsold),andfrailelderly(67–99yearsold).ThisanalysisisthefirsttodemonstratethatMDSCsandspecificallytheCD11b(+)CD15(+)MDSCsubsetareincreasedwithage.ProinflammatorycytokinesthatarerequiredforthedifferentiationofMDSCs(e.g.,TNF‐α,IL‐6,andIL‐1β)weresimilarlyfoundtobeincreasedintheserumofthefrailelderly.Furthermore,theproportionofMDSCsandtheCD11b(+)CD15(+)subsetwerefoundtobeelevatedsignificantlyinelderlydonorswithahistoryofcancer.Thisage‐relatedelevationinthefrequencyofMDSCsmaycontributetotheincreasedcancerincidencethatoccurswithage.FurtherinvestigationintothefunctionalconsequencesofelevatedMDSCswillprovidevaluableinsightintotheprogressionofage‐relatedpathologies...

【 授权许可】

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