Blood CD33(+)HLA-DR(−) myeloid-derived suppressor cells are increased with age and a history of cancer

Journal of Leukocyte Biology

Dawn M. E. Bowdish,–¹  Chris P. Verschoor,–¹  Jonathan L. Bramson,– and¹  Mark Loeb¹  Alina Lelic,–¹  Jennie Johnstone¹  Mojtaba Habibagahi,–¹  Jamie Millar,–¹  Michael G. Dorrington,–¹ 

[1]Departments of Pathology and Molecular Medicine,  Clinical Epidemiology and Biostatistics, Medicine, and M. G. DeGroote Institute for Infectious Disease Research, and –McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada and Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran

关键词: aging;    elderly;    inflammaging;    mortality;   

DOI  :  10.1189/jlb.0912461

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

As we age, the composition of our peripheral leukocytes changes dramatically. Many of these alterations contribute to the general immune dysfunction that burdens the elderly, which in turn, contributes to increased susceptibility to disease. MDSCs represent a heterogeneous population of immunosuppressive leukocytes that are elevated in the peripheral blood of cancer patients. Given the relation between cancer incidence and age, this study examined the frequency of peripheral blood CD33(+)HLA-DR(−) MDSCs across three cohorts: healthy adults (19–59 years old), community-dwelling seniors (61–76 years old), and frail elderly (67–99 years old). This analysis is the first to demonstrate that MDSCs and specifically the CD11b(+)CD15(+) MDSC subset are increased with age. Proinflammatory cytokines that are required for the differentiation of MDSCs (e.g., TNF-α, IL-6, and IL-1β) were similarly found to be increased in the serum of the frail elderly. Furthermore, the proportion of MDSCs and the CD11b(+)CD15(+) subset were found to be elevated significantly in elderly donors with a history of cancer. This age-related elevation in the frequency of MDSCs may contribute to the increased cancer incidence that occurs with age. Further investigation into the functional consequences of elevated MDSCs will provide valuable insight into the progression of age-related pathologies.

【 授权许可】

Unknown