期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells | |
| 关键词: dendritic cells; CD26; T cell activation; Th1; CD45RA/CD45RO; Foxp3; | |
| DOI : 10.1189/jlb.1009696 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
ByinteractingwithCD26ontheCD4+TcellsurfaceandwiththeAdoRA2BontheDCsurface,ADAtriggersacostimulatorysignalforhumanTcells.TheaimofthisstudywastoknowwhetherADA‐mediatedcostimulationplaysaroleinthedifferentiationofTcells.TheresultsshowthatirrespectiveofitsenzymaticactivityanddependentonTNF‐α,IFN‐γ,andIL‐6action,ADAenhancedthedifferentiationofCD4+CD45RA+CD45RO–naïveTcellstowardCD4+CD25+CD45RO+TeffsandCD4+CD45RA–CD45RO+memoryTcells.Furthermore,ADApotentiatedgenerationofCD4+CD25highFoxp3+TregsbyamechanismthatseemstobemainlydependentontheenzymaticactivityofADA.Interestingly,anADA‐mediatedincreaseonTeff,memoryTcell,andTreggenerationoccurred,notonlyincoculturesfromhealthyindividualsbutalsofromHIV‐infectedpatients.ThesedatasuggestthatADAisarelevantmodulatorofCD4+Tcelldifferentiation,evenincellsfromimmunologicallycompromisedindividuals...【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901232306469ZK.pdf | 2072KB |  download |
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