Simian immunodeficiency virus infection and immune responses in the pig‐tailed macaque testis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: CD4+ T cells;    CD8+ T cells;    immune privilege;    HIV;    testicular macrophages;   

DOI  :  10.1189/jlb.4A0914-438R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Thetestisisasiteofimmuneprivilegeinrodents,andthereisevidencethatTcellresponsesarealsosuppressedintheprimatetestis.LocalimmunosuppressionisapotentialmechanismforHIVpersistenceintissuereservoirsthatfewstudieshaveexamined.Theresponseofthepig‐tailedmacaquetestistoSIVmac239infectionwascharacterizedtotestthispossibility.Testesweresurgicallyremovedduringearly‐chronic(10wk)andlate‐chronic(24–30wk)SIVinfectionin4animalsandcomparedwiththosefrom7uninfectedanimals.SIVinfectioncausedonlyminordisruptiontotheseminiferousepitheliumwithoutmarkedevidenceofinflammationorconsistentchangesintotalintratesticularleukocytenumbers.InfectionalsoledtoanincreaseintherelativeproportionoftesticulareffectormemoryCD8+TcellnumbersandacorrespondingreductionincentralmemoryCD4+Tcells.Adecreaseintherelativeproportionofresident‐typeCD163+macrophagesandDCswasalsoobserved.SIV‐specificCD8+Tcellsweredetectableinthetestis,10–11wkafterinfectionbystainingwithSIVGag‐specificorTat‐specificMHC‐Itetramers.However,testicularCD8+Tcellsfromtheinfectedanimalshadsuppressedcytokineresponsestomitogenactivation.TheseresultssupportthepossibilitythatlocalimmunosuppressioninthetestismayberestrictingtheabilityofTcellstorespondtoSIVorHIVinfection.LocalimmunosuppressioninthetestismaybeanunderexploredmechanismallowingHIVpersistence...

【 授权许可】

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