Mediator Complex Subunit MED1 Protein Expression Is Decreased during Bladder Cancer Progression

Frontiers in Medicine

Niklas Klümper¹ 

关键词: mediator complex;    mediator;    bladder cancer;    MED1;    immunohistochemistry;   

DOI  :  10.3389/fmed.2017.00030

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

IntroductionBladder cancer (BCa) is among the most frequent cancer entities and relevantly contributes to cancer-associated deaths worldwide. The multi-protein Mediator complex is a central regulator of the transcriptional machinery of protein-coding genes and has been described to be altered in several malignancies. MED1, a subunit of the tail module, was described to negatively modulate expression of metastasis-related genes and to be downregulated in melanoma and lung cancer. In contrast, MED1 hyperactivity was described in breast and prostate cancer, likely due its function as a hub for nuclear hormone receptors. So far, only little is known about the function of the Mediator complex in BCa. The aim of this study was therefore to investigate the role of MED1 in BCa as a prognostic biomarker and a biomarker of disease progression.

【 授权许可】

CC BY