CDK8-Novel Therapeutic Opportunities

Pharmaceuticals

Veronika Sexl¹  Ingeborg Menzl¹  Agnieszka Witalisz-Siepracka¹ 

[1] Institute of Pharmacology and Toxicology, University of Veterinary Medicine, 1210 Vienna, Austria;

关键词: CDK8;    mediator complex;    cancer;   

DOI  :  10.3390/ph12020092

来源: DOAJ

【 摘 要 】

Improvements in cancer therapy frequently stem from the development of new small-molecule inhibitors, paralleled by the identification of biomarkers that can predict the treatment response. Recent evidence supports the idea that cyclin-dependent kinase 8 (CDK8) may represent a potential drug target for breast and prostate cancer, although no CDK8 inhibitors have entered the clinics. As the available inhibitors have been recently reviewed, we focus on the biological functions of CDK8 and provide an overview of the complexity of CDK8-dependent signaling throughout evolution and CDK8-dependent effects that may open novel treatment avenues.

【 授权许可】

Unknown