Innate Immunity | |
Dietary L-arginine supplementation alleviates liver injury caused by Escherichia coli LPS in weaned pigs: | |
QuanLi1  | |
关键词: Arginine; weaned pigs; lipopolysaccharide; Toll-like receptor 4; nuclear factor-κB; liver injury; | |
DOI : 10.1177/1753425912441955 | |
学科分类:生物科学(综合) | |
来源: Sage Journals | |
【 摘 要 】
This study was conducted to evaluate whether dietary supplementation with L-arginine (Arg) could attenuate Escherichia coli LPS-induced liver injury through the TLR4 signaling pathway in weaned pigs. Eighteen weaned pigs were allotted to three treatments: non-challenged control, LPS challenged control and LPS + 0.5% Arg. On d 18, pigs were injected with LPS at 100 µg/kg of body weight (BW) or sterile saline. Blood samples were obtained at 4 h post-injection. Pigs were then sacrificed for the collection of liver samples. Arg supplementation (0.5%) alleviated liver morphological impairment, including hepatocyte caryolysis, karyopycnosis and fibroblast proliferation induced by LPS challenge; it mitigated the increase of serum aspartate aminotransferase and alkaline phosphatase activities induced by LPS (P < 0.05); it prevented the increase of hepatic TNF-α, malondialdehyde contents and mast cell number induced by LPS administration (P < 0.05); and it attenuated the elevation of hepatic NF-κB and TLR4-positiv...
【 授权许可】
CC BY
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RO201901226308891ZK.pdf | 627KB | download |