Dietary L-arginine supplementation alleviates liver injury caused by Escherichia coli LPS in weaned pigs:

Innate Immunity

QuanLi¹ 

关键词: Arginine;    weaned pigs;    lipopolysaccharide;    Toll-like receptor 4;    nuclear factor-κB;    liver injury;   

DOI  :  10.1177/1753425912441955

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

This study was conducted to evaluate whether dietary supplementation with L-arginine (Arg) could attenuate Escherichia coli LPS-induced liver injury through the TLR4 signaling pathway in weaned pigs. Eighteen weaned pigs were allotted to three treatments: non-challenged control, LPS challenged control and LPS + 0.5% Arg. On d 18, pigs were injected with LPS at 100 µg/kg of body weight (BW) or sterile saline. Blood samples were obtained at 4 h post-injection. Pigs were then sacrificed for the collection of liver samples. Arg supplementation (0.5%) alleviated liver morphological impairment, including hepatocyte caryolysis, karyopycnosis and fibroblast proliferation induced by LPS challenge; it mitigated the increase of serum aspartate aminotransferase and alkaline phosphatase activities induced by LPS (P < 0.05); it prevented the increase of hepatic TNF-α, malondialdehyde contents and mast cell number induced by LPS administration (P < 0.05); and it attenuated the elevation of hepatic NF-κB and TLR4-positiv...

【 授权许可】

CC BY