Antibody equivalent molecules of the innate immune system: parallels between innate and adaptive immune proteins:

Innate Immunity

NadesPalaniyar¹ 

关键词: antibodies;    innate immune antibodies;    ante-antibodies;    collectins;    ficolins;    peptidoglycan-recognition proteins;    defensins;    cathelicidins;    agglutinin;    gp-340;    DMBT1;    pentraxins;    C1q;    natural IgM;    innate immune cells;    apoptotic cell clearance;    TLR;    NLR;   

DOI  :  10.1177/1753425910370498

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Soluble pattern-recognition innate immune proteins functionally resemble the antibodies of the adaptive immune system. Two major families of such proteins are ficolins and collectins or collagenous lectins (e.g. mannose-binding lectin [MBL], surfactant proteins [SP-A and SP-D] and conglutinin). In general, subunits of ficolins and collectins recognize the carbohydrate arrays of their targets via globular trimeric carbohydrate-recognition domains (CRDs) whereas IgG, IgM and other antibody isotypes recognize proteins via dimeric antigen-binding domains (Fab). Considering the structure and functions of these proteins, ficolins and MBL are analogous to molecules with the complement activating functions of C1q and the target recognition ability of IgG. Although the structure of SP-A is similar to MBL, it does not activate the complement system. Surfactant protein-D and conglutinin could be considered as the collagenous non-complement activating giant IgMs of the innate immune system. Proteins such as peptidogl...

【 授权许可】

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