Review: Chemical and structural modifications of pulmonary collectins and their functional consequences:

Innate Immunity

Elena N.Atochina-Vasserman¹ 

关键词: collectins;    surfactant proteins;    nitric oxide;    biomarker;    lung;   

DOI  :  10.1177/1753425910368871

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

The lung is continuously exposed to inhaled pathogens (toxic pollutants, micro-organisms, environmental antigens, allergens) from the external environment. In the broncho-alveolar space, the critical balance between a measured protective response against harmful pathogens and an inappropriate inflammatory response to harmless particles is discerned by the innate pulmonary immune system. Among its many components, the surfactant proteins and specifically the pulmonary collectins (surfactant proteins A [SP-A] and D [SP-D]) appear to provide important contributions to the modulation of host defense and inflammation in the lung. Many studies have shown that multimerization of SP-A and SP-D are important for efficient local host defense including neutralization and opsonization of influenza A virus, binding Pneumocystis murina and inhibition of LPS-induced inflammatory cell responses. These observations strongly imply that oligomerization of collectins is a critical feature of its function. However, during the...

【 授权许可】

CC BY