Mechanical Forces in Fetal Lung Development: Opportunities for Translational Research

Frontiers in Pediatrics

Juan Sanchez-Esteban¹ 

关键词: mechanical forces;    lung development;    tracheal ligation;    growth factors;    heparin-binding EGF-like growth factor;   

DOI  :  10.3389/fped.2013.00051

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Pulmonary hypoplasia secondary to congenital diaphragmatic hernia, oligohydramnios, etc., is an important cause of neonatal morbidity and mortality. In fact, pulmonary hypoplasia is the most common finding (up to 26%) in neonatal autopsies (1). Moreover, more than 20,000 babies are born every year in the United States before 27 weeks of gestation (canalicular stage of lung development). These disorders have in common an incomplete development of the lungs. In addition to the risk of death, these conditions can also cause severe respiratory distress at birth and serious long-term morbidities (2). Currently, the management is primarily supportive and there are not specific treatments designed to accelerate the development of the lungs.

【 授权许可】

CC BY