Growth factors in lung development and disease: friends or foe?

Respiratory Research

Wellington V Cardoso¹  Tushar J Desai¹ 

[1] Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA

关键词: lung injury-repair;    lung development;    growth factors;    airway branching;   

Others  :  1227419
DOI  :  10.1186/rr169

 received in 2001-06-19, accepted in 2001-08-09,  发布年份 2001

【 摘 要 】

Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung. Altered expression of growth factors, such as transforming growth factor β1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions. In this paper, we discuss the dual role of these molecules in mediating beneficial feedback responses or responses that can further damage lung integrity; we shall also discuss the basis for their prospective use as therapeutic agents.

【 授权许可】

   
2001 BioMed Central Ltd

【 图 表 】

Figure 1.

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