Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers:

Innate Immunity

Francieli SRuiz¹ 

关键词: Blood cells;    Human;    immune system;    REM sleep deprivation;    total sleep deprivation;   

DOI  :  10.1177/1753425910385962

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

We investigated the impact of two nights of total sleep deprivation (SD) or four nights of rapid eye movement (REM) SD on immunological parameters in healthy men. Thirty-two volunteers were randomly assigned to three protocols (control, total SD or REM SD). Both SD protocols were followed by three nights of sleep recovery. The control and REM SD groups had regular nights of sleep monitored by polysomnography. Circulating white blood cells (WBCs), T- (CD4/CD8) and B-lymphocytes, Ig classes, complement and cytokine levels were assessed daily. Two nights of total SD increased the numbers of leukocytes and neutrophils compared with baseline levels, and these levels returned to baseline after 24 h of sleep recovery. The CD4+ T-cells increased during the total SD period (one and two nights) and IgA levels decreased during the entire period of REM SD. These levels did not return to baseline after three nights of sleep recovery. Levels of monocytes, eosinophils, basophils and cytokines (IL-1β, IL-2, IL-4, IL-6, I...

【 授权许可】

CC BY