Evolution of cytokine production capacity in ancient and modern European populations

eLife

Yunus Kuijpers¹  Olivier B Bakker²  Jos WM Van der Meer³  Cheng-Jian Xu⁴  Jorge Domínguez-Andrés⁵  Martin Jaeger⁵  Leo AB Joosten⁵  Mihai G Netea⁶  Yang Li⁷  Mattias Jakobsson⁸  Jaume Bertranpetit⁹ 

[1] Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany;TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany;Department of Genetics, University Medical Centre Groningen, Nijmegen, Netherlands;Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands;Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands;Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany;TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany;Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands;Radboud Institute for Molecular Life Sciences (RIMLS), RadboudUniversity Medical Center, Nijmegen, Netherlands;Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands;Radboud Institute for Molecular Life Sciences (RIMLS), RadboudUniversity Medical Center, Nijmegen, Netherlands;Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany;Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands;Radboud Institute for Molecular Life Sciences (RIMLS), RadboudUniversity Medical Center, Nijmegen, Netherlands;Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany;TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany;Human Evolution, Department of Organismal Biology, Uppsala University, Uppsala, Sweden;Centre for Anthropological Research, Department of Anthropology and Development Studies, University of Johannesburg, Auckland Park, South Africa;Institut de Biologia Evolutiva (UPF-CSIC), Universitat Pompeu Fabra, Barcelona, Spain;

关键词: genetics;    evolution;    neolithic;    disease;    immune system;    adaptation;    Human;   

DOI  :  10.7554/eLife.64971

来源: eLife Sciences Publications, Ltd

【 摘 要 】

As our ancestors migrated throughout different continents, natural selection increased the presence of alleles advantageous in the new environments. Heritable variations that alter the susceptibility to diseases vary with the historical period, the virulence of the infections, and their geographical spread. In this study we built polygenic scores for heritable traits that influence the genetic adaptation in the production of cytokines and immune-mediated disorders, including infectious, inflammatory, and autoimmune diseases, and applied them to the genomes of several ancient European populations. We observed that the advent of the Neolithic was a turning point for immune-mediated traits in Europeans, favoring those alleles linked with the development of tolerance against intracellular pathogens and promoting inflammatory responses against extracellular microbes. These evolutionary patterns are also associated with an increased presence of traits related to inflammatory and auto-immune diseases.

【 授权许可】

CC BY