Nicotinamide’s Ups and Downs: Consequences for Fertility, Development, Longevity and Diseases of Poverty and Affluence:

International Journal of Tryptophan Research

Adrian CWilliams¹ 

关键词: Demographic;    ne;    erthal;    neolithic;    evolution;    meat;   

DOI  :  10.1177/1178646918802289

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Aims and Scope:To further explore the role of dietary nicotinamide in both brain development and diseases, particularly those of ageing. Articles cover neurodegenerative disease and cancer. Also discussed are the effects of nicotinamide, contained in meat and supplements and derived from symbionts, on the major transitions of disease and fertility from ancient times up to the present day. A key role for the tryptophan – NAD ‘de novo’ and immune tolerance pathway are discussed at length in the context of fertility and longevity and the transitions from immune paresis to Treg-mediated immune tolerance and then finally to intolerance and their associated diseases.Abstract: Nicotinamide in human evolution increased cognitive power in a positive feedback loop originally involving hunting. As the precursor to metabolic master molecule NAD it is, as vitamin B3, vital for health. Paradoxically, a lower dose on a diverse plant then cereal-based diet fuelled population booms from the Mesolithic onwards, by upping i...

【 授权许可】

CC BY