In utero exposure to LPS alters the postnatal acute-phase response in beef heifers:

Innate Immunity

Jeffery ACarroll¹ 

关键词: Acute phase response;    cattle;    lipopolysaccharide;    neutrophils;    prenatal stress;   

DOI  :  10.1177/1753425916678472

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

The potential effect of prenatal LPS exposure on the postnatal acute phase response (APR) to an LPS challenge in heifers was determined. Pregnant crossbred cows were separated into prenatal immune stimulation (PIS) and saline groups (Control). From these treatments, heifer calves were identified at weaning to subsequently receive an exogenous LPS challenge. Sickness behavior scores (SBS) were recorded and blood samples were collected at 30-min intervals from −2 to 8 h and again at 24 h relative to the LPS challenge. There was a treatment × time interaction for the change in vaginal temperature (VT) such that the change in VT was greater in Control than PIS from 150 to 250 min, yet it was greater in PIS than Control from 355 to 440 min and from 570 to 1145 min. There was also a treatment × time interaction for SBS such that scores were greater in Control than PIS at 0.5 h, yet were greater in PIS than Control from 2.5 to 4 h post-LPS. There was a tendency for a treatment × time interaction for serum concen...

【 授权许可】

CC BY