Enhancement of the acute phase response to a lipopolysaccharide challenge in steers supplemented with chromium:

Innate Immunity

Nicole CBurdick¹ 

关键词: Acute phase response;    chromium;    lipopolysaccharide;    sickness behavior;    temperature;   

DOI  :  10.1177/1753425911428964

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

The study examined the effect of chromium supplementation on the response of steers to an LPS challenge. Steers received a premix that added 0 (control; n = 10) or 0.2 mg/kg of chromium (n = 10) to the total diet on a dry matter basis for 56 d. Steers were fitted with jugular catheters and rectal temperature (RT) recording devices on d 52. Blood samples were collected and sickness behavior scores assigned to each steer relative to an LPS challenge (0.5 µg/kg) on d 55. Pre-LPS RT were greater in chromium-supplemented than in control steers. Post-LPS RT increased in both treatments, with control steers producing a greater change in RT than chromium-supplemented steers. Sickness behavior scores were greater in control than in chromium-supplemented steers post-LPS (P = 0.03). Cortisol concentrations did not differ between treatments pre-LPS. Post-LPS cortisol concentrations increased but did not differ due to treatment. Concentrations of IL-4 increased post-LPS but were not affected by treatment pre- or post-...

【 授权许可】

CC BY