Journal of Experimental Neuroscience | |
Factors Influencing Short-term Synaptic Plasticity in the Avian Cochlear Nucleus Magnocellularis: | |
Jason Tait SanchezQuinones1  | |
关键词: AMPA receptors; desensitization; development; glutamate transporters; nucleus magnocellularis; short-term synaptic depression; | |
DOI : 10.4137/JEN.S25472 | |
学科分类:生物科学(综合) | |
来源: Sage Journals | |
【 摘 要 】
Defined as reduced neural responses during high rates of activity, synaptic depression is a form of short-term plasticity important for the temporal filtering of sound. In the avian cochlear nucleus magnocellularis (NM), an auditory brainstem structure, mechanisms regulating short-term synaptic depression include pre-, post-, and extrasynaptic factors. Using varied paired-pulse stimulus intervals, we found that the time course of synaptic depression lasts up to four seconds at late-developing NM synapses. Synaptic depression was largely reliant on exogenous Ca2+-dependent probability of presynaptic neurotransmitter release, and to a lesser extent, on the desensitization of postsynaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPA-R). Interestingly, although extrasynaptic glutamate clearance did not play a significant role in regulating synaptic depression, blocking glutamate clearance at early-developing synapses altered synaptic dynamics, changing responses from depression to facilitation. These results suggest a developmental shift in the relative reliance on pre-, post-, and extrasynaptic factors in regulating short-term synaptic plasticity in NM.
【 授权许可】
CC BY
【 预 览 】
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