Hypobaric hypoxia-related impairment of pulmonary surfactant proteins A and D did not favour Pneumocystis carinii Frenkel 1999 growth in non-immunocompromised rats

Parasite

and M.C. Prévost⁴  E. Dei-Cas³  B. Perret⁴  R. Escamilla²  E.M. Aliouat¹  S. Caspar-Bauguil⁵  M.F. Vives⁴ 

[1] Parasitology-Mycology Service, Faculty of Pharmaceutical Sciences (EA3609, Lille 2 University) & Ecology of Parasitism, EA-3609-IFR- 142, Lille Pasteur Institute,France;Larrey Hospital, “Clinique des Voies Respiratoires”, 24, chemin de Pouvourville,TSA 30030,31059 Toulouse cedex 9,France;Parasitology-Mycology Service, Microbiology Department, EA3609, Faculty of Medicine, Lille 2 University, University Hospital Centre & IFR-142, Lille Pasteur Institute,France;IFR 30 INSERM U563, Purpan Hospital,BP 3028,31024 Toulouse cedex 3,France;General and Nutritional Biochemistry laboratory, Purpan Hospital,TSA 40031,31059 Toulouse cedex 9 France

关键词: hypobaric hypoxia;    altitude;    rat;    pulmonary surfactant;    pneumonia;    Pneumocystis;   

Others  :  808567
DOI  :  doi:10.1051/parasite/2008151053

 received in 2007-07-23, accepted in 2007-10-31,  发布年份 2008

【 摘 要 】

It has been suggested that patients with pulmonary surfactant impairment are more susceptible to Pneumocystis infection than healthy controls. Owing the fact that most patients with pulmonary surfactant impairment also suffer from hypoxia, we explored the effect of intermittent hypobaric hypoxia conditions on the ability of non-immunocompromised rats infected by endotracheal route with P. carinii to clear the infection from their lungs. Control rats, inoculated or not with P. carinii, were maintained in normobaric normoxic conditions, and were submitted or not to dexamethasone administration. It was found that even if hypobaric hypoxia weakened host immune mechanisms and impaired significantly the surfactant composition, mainly of surfactant proteins A and D, these changes were not enough to favour the Pneumocystis growth or to inhibit the clearing of Pneumocystis organisms from the lungs of non-immunocompromised rats. The potential influence of surfactant protein changes on Pneumocystis infection is discussed.

【 授权许可】

   
© PRINCEPS Editions, Paris, 2008