Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson’s disease

Translational Neurodegeneration

Jinhui Ding²  Lixin Sun¹  Guoxiang Liu¹  Huaibin Cai¹ 

[1] Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA;Computational Biology Core, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA

关键词: Aging;    Neurodegeneration;    α-synuclein;    Aldehyde dehydrogenase 1;    Dopaminergic neuron;    Substantia nigra pars compacta;    Parkinson’s disease;   

Others  :  1130931
DOI  :  10.1186/2047-9158-3-27

 received in 2014-10-20, accepted in 2014-12-01,  发布年份 2014

【 摘 要 】

A preferential dysfunction/loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) accounts for the main motor symptoms of Parkinson’s disease (PD), the most common degenerative movement disorder. However, the neuronal loss is not stochastic, but rather displays regionally selectivity, indicating the existence of different DA subpopulations in the SNpc. To identify the underlying molecular determinants is thereby instrumental in understanding the pathophysiological mechanisms of PD-related neuron dysfunction/loss and offering new therapeutic targets. Recently, we have demonstrated that aldehyde dehydrogenase 1 (ALDH1A1) is one such molecular determinant that defines and protects an SNpc DA neuron subpopulation preferentially affected in PD. In this review, we provide further analysis and discussion on the roles of ALDH1A1 in the function and survival of SNpc DA neurons in both rodent and human brains. We also explore the feasibility of ALDH1A1 as a potential biomarker and therapeutic target for PD.

【 授权许可】

   
2014 Cai et al.; licensee BioMed Central.

【 图 表 】

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