Endothelial perturbations and therapeutic strategies in normal tissue radiation damage

Radiation Oncology

Stanley K Liu²  Elina Korpela¹ 

[1] Department of Medical Biophysics, University of Toronto, 101 College St., Toronto M5G 1L7, Canada;Department of Radiation Oncology, University of Toronto, 149 College St., Toronto M5T 1P5, Canada

关键词: Senescence;    Inflammation;    Cell death;    Radioprotection;    Microvasculature;    Endothelial cell;    Acute radiation toxicity;    Radiotherapy;   

Others  :  1150436
DOI  :  10.1186/s13014-014-0266-7

 received in 2014-08-14, accepted in 2014-11-18,  发布年份 2014

【 摘 要 】

Most cancer patients are treated with radiotherapy, but the treatment can also damage the surrounding normal tissue. Radiotherapy side-effects diminish patients’ quality of life, yet effective biological interventions for normal tissue damage are lacking. Protecting microvascular endothelial cells from the effects of irradiation is emerging as a targeted damage-reduction strategy. We illustrate the concept of the microvasculature as a mediator of overall normal tissue radiation toxicity through cell death, vascular inflammation (hemodynamic and molecular changes) and a change in functional capacity. Endothelial cell targeted therapies that protect against such endothelial cell perturbations and the development of acute normal tissue damage are mostly under preclinical development. Since acute radiation toxicity is a common clinical problem in cutaneous, gastrointestinal and mucosal tissues, we also focus on damage in these tissues.

【 授权许可】

   
2014 Korpela and Liu; licensee BioMed Central.

【 图 表 】

Figure 1.

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