Interventional therapy for human breast cancer in nude mice with 131I gelatin microspheres (131I-GMSs) following intratumoral injection

Radiation Oncology

Xiao-Li Chen⁴  Zhuo Chen⁵  Lin Li²  Chuan-Qin Xia¹  Jian-Hong Li²  Yu Ma³  Jun-Lin Chi⁴  Chuan-Chao Li⁴ 

[1] College of Chemistry, Sichuan University, Chengdu (610041), China;Department of Nuclear Medicine and The National Key Discipline of Medical Imaging and Nuclear Medicine, West China Hospital of Sichuan University, Chengdu (610041), China;Department of Thyroid and Breast Surgery, West China Hospital of Sichuan University Chengdu (610041), China;Department of General Surgery, West China Hospital of Sichuan University, Chengdu (610041), China;Regeneration Medicine Research Center, West China Hospital of Sichuan University, Chengdu (610041), China

关键词: Biodistribution;    Treatment outcome;    Intratumoral injection;    Breast neoplasms;    Gelatin microspheres;    ¹³¹I;   

Others  :  801006
DOI  :  10.1186/1748-717X-9-144

 received in 2014-01-08, accepted in 2014-06-04,  发布年份 2014

【 摘 要 】

Introduction

The aim of this study was to investigate the effects of ¹³¹I gelatin microspheres (¹³¹I-GMS) on human breast cancer cells (MCF-7) in nude mice and the biodistribution of ¹³¹I-GMSs following intratumoral injections.

Methods

A total of 20 tumor-bearing mice were divided into a treatment group and control group and received intratumoral injections of 2.5 mci ¹³¹I-GMSs and nonradioactive GMSs, respectively. Tumor size was measured once per week. Another 16 mice received intratumoral injections of 0.4 mci ¹³¹I-GMSs and were subjected to single photon emission computed tomography (SPECT) scans and tissue radioactivity concentration measurements on day 1, 4, 8 and 16 postinjection. The 20 tumor-bearing mice received intratumoral injections of 0.4 mci [¹³¹I] sodium iodide solution and were subjected to SPECT scans and intratumoral radioactivity measurements at 1, 6, 24, 48 and 72 h postinjection. The tumors were collected for histological examination.

Results

The average tumor volume in the ¹³¹I-GMSs group on post-treatment day 21 decreased to 86.82 ± 63.6%, while it increased to 893.37 ± 158.12% in the control group (P < 0.01 vs. the ¹³¹I-GMSs group). ¹³¹I-GMSs provided much higher intratumoral retention of radioactivity, resulting in 19.93 ± 5.24% of the injected radioactivity after 16 days, whereas the control group retained only 1.83 ± 0.46% of the injected radioactivity within the tumors at 1 h postinjection.

Conclusions

¹³¹I-GMSs suppressed the growth of MCF-7 in nude mice and provided sustained intratumoral radioactivity retention. The results suggest the potential of ¹³¹I-GMSs for clinical applications in radiotherapy for breast cancer.

【 授权许可】

   
2014 Li et al.; licensee BioMed Central Ltd.

【 图 表 】

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