Pharmacokinetic properties of new antitumor radiopharmaceutical on the basis of diamond nanoporous composites labeled with rhenium-188

1st International Symposium 'Physics, Engineering and Technologies for Bio-Medicine'

医药卫生;物理学;工业技术

Petriev, V.M.^1,2 ; Tishchenko, V.K.^1 ; Kuril'Chik, A.A.^1 ; Skvortsov, V.G.^1

Tsyb Medical Radiological Research Centre - Branch, National Medical Research Radiological Centre, Ministry of Health of the Russian Federation (A. Tsyb MRCC), Korolev street, 4, Obninsk, Kaluga region

249036, Russia^1

National Research Nuclear University, MEPhI (Moscow Engineering Physics Institute), Kashirskoe shosse, 31, Moscow

115409, Russia^2

关键词: Activity levels;    Anti-cancer therapies;    Carbon-based composite materials;    Delivery systems;    Intratumoral injection;    Nanoporous composite;    Pharmacokinetic properties;    Therapeutic radionuclides;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/784/1/012044/pdf
DOI  :  10.1088/1742-6596/784/1/012044

来源: IOP

【 摘 要 】

Today the development of address therapeutic radionuclide delivery systems directly to tumor tissue is of current interest. It can be achieved by the design of drug containers of specific sizes and shapes from carbon-based composite materials. It will be allowed to enhance the efficacy of anticancer therapy and avoid serious side effects. In this work we studied the pharmacokinetic properties of nanodiamond nanoporous composite labeled with rhenium-188 in rats with hepatocholangioma PC-1 after intratumoral injection. It was established that substantial part of injected radioactivity remained in tumor tissue. Within three hours after188Re-nanoporous composites injection activity in tumor constituted 79.1-91.3% of injected dose (ID). Then activity level declined to 45.9% ID at 120 hours. No more than 1.34% ID entered the bloodstream. In soft organs and tissues, except thyroid gland, the content of compound didn't exceed 0.3% ID/g. The highest activity in thyroid gland was 6.95% ID/g. In conclusion, received results suggest188Re-nanoporous composites can be promising radionuclide delivery systems for cancer treatment.