Metabolic effects of milk protein intake strongly depend on pre-existing metabolic and exercise status

Nutrition & Metabolism

Loren Cordain⁴  Staffan Lindeberg¹  Pedro Carrera-Bastos¹  Swen Malte John²  Gerd Schmitz³  Bodo C Melnik² 

[1] Center for Primary Health Care Research, Lund University, Lund, Sweden;Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany;Institute of Clinical Chemistry and Laboratory Medicine, University Clinics of Regensburg, Regensburg, Germany;Department of Health and Exercise Science, Colorado State University, Fort Collins CO 80523, USA

关键词: Prostate cancer;    Obesity;    mTORC1;    microRNA;    Milk proteins;    Insulin resistance;    Glutaminolysis;    Branched-chain amino acids;    Body weight;    Adipogenesis;   

Others  :  803179
DOI  :  10.1186/1743-7075-10-60

 received in 2013-07-16, accepted in 2013-09-28,  发布年份 2013

【 摘 要 】

Milk protein intake has recently been suggested to improve metabolic health. This Perspective provides evidence that metabolic effects of milk protein intake have to be regarded in the context of the individual’s pre-existing metabolic and exercise status. Milk proteins provide abundant branched-chain amino acids (BCAAs) and glutamine. Plasma BCAAs and glutamine are increased in obesity and insulin resistance, but decrease after gastric bypass surgery resulting in weight loss and improved insulin sensitivity. Milk protein consumption results in postprandial hyperinsulinemia in obese subjects, increases body weight of overweight adolescents and may thus deteriorate pre-existing metabolic disturbances of obese, insulin resistant individuals.

【 授权许可】

   
2013 Melnik et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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