Obesity, Inflammation and Acute Myocardial Infarction - Expression of leptin, IL-6 and high sensitivity-CRP in Chennai based population

Thrombosis Journal

Malathi Ragunathan²  Manohar Ganesan¹  Nalini Devarajan²  Karthick Rajendran² 

[1] Department of Cardiology, Stanley Medical College, Chennai, -600001, India;Department of Genetics, Dr.ALMPGIBMS, University of Madras, Chennai, -600113, India

关键词: Acute myocardial infarction;    Cardiovascular disease;    Obesity;    CRP;    IL-6;    Leptin;   

Others  :  838885
DOI  :  10.1186/1477-9560-10-13

 received in 2012-01-31, accepted in 2012-08-02,  发布年份 2012

【 摘 要 】

Background

Obesity, characterised by increased fat mass and is currently regarded as a pro-inflammatory state and often associated with increased risk of cardiovascular diseases (CVD) including Myocardial infarction. There is an upregulation of inflammatory markers such as interleukin-6, interleukin-6 receptor and acute phase protein CRP in Acute Myocardial Infarction (AMI) patients but the exact mechanism linking obesity and inflammation is not known. It is of our interest to investigate if serum leptin (ob gene product) is associated with AMI and correlated with inflammatory proteins namely Interleukin-6 (IL-6) and high sensitivity - C reactive protein (hs-CRP).

Results

Serum leptin levels were significantly higher in AMI patients when compared to Non-CVD controls. IL-6 and hs-CRP were also elevated in the AMI group and leptin correlated positively with IL-6 and hs-CRP. Incidentally this is the first report from Chennai based population, India.

Conclusions

The strong correlation between serum levels of leptin and IL-6 implicates an involvement of leptin in the upregulation of inflammatory cytokines during AMI. We hypothesise that the increase in values of IL-6, hs-CRP and their correlation to leptin in AMI patients could be due to participation of leptin in the signaling cascade after myocardial ischemia.

【 授权许可】

   
2012 Karthick et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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