Obesity, Inflammation and Acute Myocardial Infarction - Expression of leptin, IL-6 and high sensitivity-CRP in Chennai based population

Thrombosis Journal

Original Basic Research

Manohar Ganesan¹  Karthick Rajendran²  Nalini Devarajan²  Malathi Ragunathan² 

[1] Department of Cardiology, Stanley Medical College, 600001, Chennai, India;Department of Genetics, Dr.ALMPGIBMS, University of Madras, 600113, Chennai, India;

关键词: Leptin;    IL-6;    CRP;    Obesity;    Cardiovascular disease;    Acute myocardial infarction;   

DOI  :  10.1186/1477-9560-10-13

 received in 2012-01-31, accepted in 2012-08-02,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundObesity, characterised by increased fat mass and is currently regarded as a pro-inflammatory state and often associated with increased risk of cardiovascular diseases (CVD) including Myocardial infarction. There is an upregulation of inflammatory markers such as interleukin-6, interleukin-6 receptor and acute phase protein CRP in Acute Myocardial Infarction (AMI) patients but the exact mechanism linking obesity and inflammation is not known. It is of our interest to investigate if serum leptin (ob gene product) is associated with AMI and correlated with inflammatory proteins namely Interleukin-6 (IL-6) and high sensitivity - C reactive protein (hs-CRP).ResultsSerum leptin levels were significantly higher in AMI patients when compared to Non-CVD controls. IL-6 and hs-CRP were also elevated in the AMI group and leptin correlated positively with IL-6 and hs-CRP. Incidentally this is the first report from Chennai based population, India.ConclusionsThe strong correlation between serum levels of leptin and IL-6 implicates an involvement of leptin in the upregulation of inflammatory cytokines during AMI. We hypothesise that the increase in values of IL-6, hs-CRP and their correlation to leptin in AMI patients could be due to participation of leptin in the signaling cascade after myocardial ischemia.

【 授权许可】

Unknown   
© Karthick et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.