Interleukin-6 as inflammatory marker referring to multiple organ dysfunction syndrome in severely injured children

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Michael Frink²  Frank Hildebrand⁵  Axel Gänsslen³  Julia Helga Karla Andruszkow⁴  Ulf Brunnemer²  Michael Sasse¹  Janika Fischer²  Hagen Andruszkow² 

[1] Clinic for Paediatric Cardiology and Internal Medicine, Carl Neuberg-Str. 1, 30625 Hannover, Germany;Trauma Department, Hannover Medical School, Carl Neuberg-Str. 1, 30625 Hannover, Germany;Department for Trauma, Hand and Reconstructive Surgery, Medical Center Wolfsburg, Sauerbruchstr 7, 38440 Wolfsburg, Germany;Institute of Pathology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany;Department of Orthopaedic Trauma at Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany

关键词: IL-6;    Interleukin-6;    Inflammatory response;    MODS;    Multiple organ failure;    Multiple organ dysfunction syndrome;    Pediatric trauma;    Multiple trauma;   

Others  :  804923
DOI  :  10.1186/1757-7241-22-16

 received in 2013-11-03, accepted in 2014-02-11,  发布年份 2014

【 摘 要 】

Background

Despite the suggestion that the inflammatory response in traumatized children is functionally unique, prognostic markers predicting pediatric multiple organ failure are lacking. We intended to verify whether Interleukin-6 (IL-6) displays a pivotal role in pediatric trauma similar to adults.

Methods

Traumatized children less than 18 years of age with an Injury Severity Score >9 points and consecutive admission to the hospital’s pediatric intensive care unit were included. Organ function was evaluated according to the score by Marshall et al. while IL-6 levels were measured repetitively every morning.

Results

59 traumatized children were included (8.4 ± 4.4 years; 57.6% male gender). Incidence of MODS was 11.9%. No differences were found referring to age, gender, injury distribution or overall injury severity between children with and without MODS. Increased IL-6 levels during hospital admission were associated with injury severity (Spearman correlation: r = 0.522, p < 0.001), while an inconsistent association towards the development of MODS was proven at that time point (Spearman correlation: r = 0.180, p = 0.231; Pearson's correlation: r = 0.297, p = 0.045). However, increased IL-6 levels during the first two days were no longer associated with the injury severity but a significant correlation to MODS was measured.

Conclusions

The presented prospective study is the first providing evidence for a correlation of IL-6 levels with injury severity and the incidence of MODS in traumatized children.

【 授权许可】

   
2014 Andruszkow et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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