Green tea intake is associated with urinary estrogen profiles in Japanese-American women

Nutrition Journal

Regina G Ziegler¹  Timothy D Veenstra¹  Larry K Keefer¹  Xia Xu¹  Anna H Wu¹  Ruth M Pfeiffer¹  Barbara J Fuhrman¹ 

[1] Current address: Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, 4301 W. Markham St. #820, Little Rock, AR, 72205, USA

关键词: Middle-aged;    Female;    Human;    Risk factors;    Breast neoplasms;    Camellia sinensis;    Green tea;    Metabolism;    Estrogens;   

Others  :  823589
DOI  :  10.1186/1475-2891-12-25

 received in 2012-07-23, accepted in 2012-12-30,  发布年份 2013

【 摘 要 】

Scope

Intake of green tea may reduce the risk of breast cancer; polyphenols in this drink can influence enzymes that metabolize estrogens, known causal factors in breast cancer etiology.

Methods and results

We examined the associations of green tea intake (<1 time/week, 1-6 times weekly, or 7+ times weekly) with urinary estrogens and estrogen metabolites (jointly EM) in a cross-sectional sample of healthy Japanese American women, including 119 premenopausal women in luteal phase and 72 postmenopausal women. We fit robust regression models to each log-transformed EM concentration (picomoles per mg creatinine), adjusting for age and study center. In premenopausal women, intake of green tea was associated with lower luteal total EM (P trend = 0.01) and lower urinary 16-pathway EM (P trend = 0.01). In postmenopausal women, urinary estrone and estradiol were approximately 20% and 40% lower (P trend = 0.01 and 0.05, respectively) in women drinking green tea daily compared to those drinking <1 time/week. Adjustment for potential confounders (age at menarche, parity/age at first birth, body mass index, Asian birthplace, soy) did not change these associations.

Conclusions

Findings suggest that intake of green tea may modify estrogen metabolism or conjugation and in this way may influence breast cancer risk.

【 授权许可】

   
2013 Fuhrman et al; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Matsuno RK, Anderson WF, Yamamoto S, Tsukuma H, Pfeiffer RM, Kobayashi K, Devesa SS, Levine PH: Early- and late-onset breast cancer types among women in the United States and Japan. Cancer Epidemiol Biomarkers Prev 2007, 16(7):1437-1442.
• [2]Ziegler RG, Hoover RN, Pike MC, Hildesheim A, Nomura AM, West DW, Wu-Williams AH, Kolonel LN, Horn-Ross PL, Rosenthal JF, et al.: Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst 1993, 85(22):1819-1827.
• [3]Yang CS, Wang X, Lu G, Picinich SC: Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 2009, 9(6):429-439.
• [4]Wu AH, Butler LM: Green tea and breast cancer. Mol Nutr Food Res 2011, 55(6):921-930.
• [5]Boehm K, Borrelli F, Ernst E, Habacher G, Hung SK, Milazzo S, Horneber M: Green tea (camellia sinensis) for the prevention of cancer. Cochrane Database Syst Rev 2009, (Issue 3):Art. No.: CD005004.
• [6]Wu AH, Arakawa K, Stanczyk FZ, Van Den Berg D, Koh WP, Yu MC: Tea and circulating estrogen levels in postmenopausal Chinese women in Singapore. Carcinogenesis 2005, 26(5):976-980.
• [7]Larsson SC, Bergkvist L, Wolk A: Coffee and black tea consumption and risk of breast cancer by estrogen and progesterone receptor status in a Swedish cohort. Cancer Causes Control 2009, 20(10):2039-2044.
• [8]Ishitani K, Lin J, Manson JE, Buring JE, Zhang SM: Caffeine consumption and the risk of breast cancer in a large prospective cohort of women. Arch Intern Med 2008, 168(18):2022-2031.
• [9]Ganmaa D, Willett WC, Li TY, Feskanich D, van Dam RM, Lopez-Garcia E, Hunter DJ, Holmes MD: Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-up. Int J Cancer 2008, 122(9):2071-2076.
• [10]Michels KB, Holmberg L, Bergkvist L, Wolk A: Coffee, tea, and caffeine consumption and breast cancer incidence in a cohort of Swedish women. Ann Epidemiol 2002, 12(1):21-26.
• [11]Xu X, Duncan AM, Merz-Demlow BE, Phipps WR, Kurzer MS: Menstrual cycle effects on urinary estrogen metabolites. J Clin Endocrinol Metab 1999, 84(11):3914-3918.
• [12]Falk RT, Rossi SC, Fears TR, Sepkovic DW, Migella A, Adlercreutz H, Donaldson J, Bradlow HL, Ziegler RG: A new ELISA kit for measuring urinary 2-hydroxyestrone, 16alpha-hydroxyestrone, and their ratio: reproducibility, validity, and assay performance after freeze-thaw cycling and preservation by boric acid. Cancer Epidemiol Biomarkers Prev 2000, 9(1):81-87.
• [13]Xu X, Veenstra TD, Fox SD, Roman JM, Issaq HJ, Falk R, Saavedra JE, Keefer LK, Ziegler RG: Measuring fifteen endogenous estrogens simultaneously in human urine by high-performance liquid chromatography-mass spectrometry. Anal Chem 2005, 77(20):6646-6654.
• [14]Fuhrman BJ, Pfeiffer R, Xu X, Wu AH, Korde L, Gail MH, Keefer LK, Veenstra TD, Hoover RN, Ziegler RG: Soy intake is associated with increased 2-hydroxylation and decreased 16alpha-hydroxylation of estrogens in Asian-American women. Cancer Epidemiol Biomarkers Prev 2009, 18(10):2751-2760.
• [15]Flores OR, Sun L, Vaziri ND, Miyada DS: Colorimetric rate method for the determination of creatinine as implemented by the beckman creatinine analyzer 2. Am J Med Technol 1980, 46(11):792-798.
• [16]U.S. Department of Agriculture Agricultural Research Service: USDA National Nutrient Database for Standard Reference, Release 22. Nutrient Data Laboratory Home Page. 2009. http://www.ars.usda.gov/Services/docs.htm?docid=20960 webcite, accessed June of 2010
• [17]Oba S, Nagata C, Nakamura K, Fujii K, Kawachi T, Takatsuka N, Shimizu H: Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women. Br J Nutr 2010, 103(3):453-459.
• [18]Fuhrman BJ, Brinton L, Pfeiffer RM, Xu X, Veenstra TD, Teter BE, Byrne C, Dallal C, Barba M, Muti P, et al.: Estrogen metabolism and mammographic density in postmenopausal women: a cross-sectional study. Cancer Epidemiol Biomarkers Prev 2012, 21(9):1582-1591.
• [19]Eliassen AH, Ziegler RG, Rosner B, Veenstra TD, Roman JM, Xu X, Hankinson SE: Reproducibility of fifteen urinary estrogens and estrogen metabolites over a 2- to 3-year period in premenopausal women. Cancer Epidemiol Biomarkers Prev 2009, 18(11):2860-2868.
• [20]Wu AH, Spicer D, Stanczyk FZ, Tseng CC, Yang CS, Pike MC: Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women. Cancer Prev Res (Phila) 2012, 5(3):393-402.
• [21]Nagata C, Kabuto M, Shimizu H: Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women. Nutr Cancer 1998, 30(1):21-24.
• [22]Wu AH, Yu MC: Tea, hormone-related cancers and endogenous hormone levels. Mol Nutr Food Res 2006, 50(2):160-169.
• [23]Goodin MG, Rosengren RJ: Epigallocatechin gallate modulates CYP450 isoforms in the female swiss-webster mouse. Toxicol Sci 2003, 76(2):262-270.
• [24]Goodin MG, Bray BJ, Rosengren RJ: Sex- and strain-dependent effects of epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) in the mouse. Food Chem Toxicol 2006, 44(9):1496-1504.
• [25]Aubertin-Leheudre M, Gorbach S, Woods M, Dwyer JT, Goldin B, Adlercreutz H: Fat/fiber intakes and sex hormones in healthy premenopausal women in USA. J Steroid Biochem Mol Biol 2008, 112(1–3):32-39.
• [26]Eliassen AH, Spiegelman D, Xu X, Keefer LK, Veenstra TD, Barbieri RL, Willett WC, Hankinson SE, Ziegler RG: Urinary estrogens and estrogen metabolites and subsequent risk of breast cancer among premenopausal women. Cancer Res 2012, 72(3):696-706.
• [27]Satoh K, Sakamoto Y, Ogata A, Nagai F, Mikuriya H, Numazawa M, Yamada K, Aoki N: Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats. Food Chem Toxicol 2002, 40(7):925-933.
• [28]Monteiro R, Azevedo I, Calhau C: Modulation of aromatase activity by diet polyphenolic compounds. J Agric Food Chem 2006, 54(10):3535-3540.
• [29]Monteiro R, Assuncao M, Andrade JP, Neves D, Calhau C, Azevedo I: Chronic green tea consumption decreases body mass, induces aromatase expression, and changes proliferation and apoptosis in adult male rat adipose tissue. J Nutr 2008, 138(11):2156-2163.
• [30]Xu WH, Dai Q, Xiang YB, Long JR, Ruan ZX, Cheng JR, Zheng W, Shu XO: Interaction of soy food and tea consumption with CYP19A1 genetic polymorphisms in the development of endometrial cancer. Am J Epidemiol 2007, 166(12):1420-1430.
• [31]Cavalieri EL, Rogan EG, Chakravarti D: Initiation of cancer and other diseases by catechol ortho-quinones: a unifying mechanism. Cellular and molecular life sciences: CMLS 2002, 59(4):665-681.
• [32]Zhu BT: Catechol-O-Methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics: importance in pathophysiology and pathogenesis. Curr Drug Metab 2002, 3(3):321-349.
• [33]Key T, Appleby P, Barnes I, Reeves G: Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002, 94(8):606-616.
• [34]Onland-Moret NC, Kaaks R, van Noord PA, Rinaldi S, Key T, Grobbee DE, Peeters PH: Urinary endogenous sex hormone levels and the risk of postmenopausal breast cancer. Br J Cancer 2003, 88(9):1394-1399.
• [35]Key TJ, Wang DY, Brown JB, Hermon C, Allen DS, Moore JW, Bulbrook RD, Fentiman IS, Pike MC: A prospective study of urinary oestrogen excretion and breast cancer risk. Br J Cancer 1996, 73(12):1615-1619.
• [36]James RE, Lukanova A, Dossus L, Becker S, Rinaldi S, Tjonneland A, Olsen A, Overvad K, Mesrine S, Engel P, et al.: Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study. Cancer Prev Res (Phila) 2011, 4(10):1626-1635.
• [37]Eliassen AH, Missmer SA, Tworoger SS, Spiegelman D, Barbieri RL, Dowsett M, Hankinson SE: Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. J Natl Cancer Inst 2006, 98(19):1406-1415.
• [38]Kaaks R, Berrino F, Key T, Rinaldi S, Dossus L, Biessy C, Secreto G, Amiano P, Bingham S, Boeing H, et al.: Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst 2005, 97(10):755-765.
• [39]Key TJ, Sharp GB, Appleby PN, Beral V, Goodman MT, Soda M, Mabuchi K: Soya foods and breast cancer risk: a prospective study in Hiroshima and Nagasaki, Japan. Br J Cancer 1999, 81(7):1248-1256.
• [40]Suzuki Y, Tsubono Y, Nakaya N, Suzuki Y, Koizumi Y, Tsuji I: Green tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan. Br J Cancer 2004, 90(7):1361-1363.
• [41]Dai Q, Shu XO, Li H, Yang G, Shrubsole MJ, Cai H, Ji B, Wen W, Franke A, Gao YT, et al.: Is green tea drinking associated with a later onset of breast cancer? Ann Epidemiol 2010, 20(1):74-81.
• [42]Ogunleye AA, Xue F, Michels KB: Green tea consumption and breast cancer risk or recurrence: a meta-analysis. Breast Cancer Res Treat 2010, 119(2):477-484.
• [43]Xu X, Keefer LK, Ziegler RG, Veenstra TD: A liquid chromatography-mass spectrometry method for the quantitative analysis of urinary endogenous estrogen metabolites. Nat Protoc 2007, 2(6):1350-1355.
• [44]Zhu BT, Taneja N, Loder DP, Balentine DA, Conney AH: Effects of tea polyphenols and flavonoids on liver microsomal glucuronidation of estradiol and estrone. J Steroid Biochem Mol Biol 1998, 64(3–4):207-215.