Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study

Respiratory Research

Isabelle Romieu⁶  Stephanie J London²  Huiling Li²  Albino Barraza-Villarreal⁴  Matiana Ramírez-Aguilar⁷  Blanca E Del Río-Navarro¹  Juan J Sienra-Monge¹  Nan M Laird⁵  Diane R Gold³  Joel Schwartz³  Douglas W Dockery³  Hortensia Moreno-Macías⁸ 

[1] Hospital Infantil “Federico Gómez”, México City, Mexico;U.S. Department of Health and Human Services, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, , USA;Environmental Health Department, Harvard School of Public Health, Boston, MA, USA;Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico;Biostatistics Department, Harvard School of Public Health, Boston, MA, USA;International Agency for Research on Cancer, Lyon, France;Comisión Federal para la Protección contra Riesgos Sanitarios, SSA, México City, Mexico;Universidad Autónoma Metropolitana, Unidad Iztapalapa, Avenida San Rafael Atlixco 186, edificio H-001, Col. Vicentina, 09430, D F, México City, Mexico

关键词: Vitamin C;    Mexico City;    Antioxidant genes;    Asthmatic children;    Air pollution;   

Others  :  796539
DOI  :  10.1186/1465-9921-14-14

 received in 2012-09-26, accepted in 2013-01-24,  发布年份 2013

【 摘 要 】

Background

We previously reported that asthmatic children with GSTM1 null genotype may be more susceptible to the acute effect of ozone on the small airways and might benefit from antioxidant supplementation. This study aims to assess the acute effect of ozone on lung function (FEF_25-75) in asthmatic children according to dietary intake of vitamin C and the number of putative risk alleles in three antioxidant genes: GSTM1, GSTP1 (rs1695), and NQO1 (rs1800566).

Methods

257 asthmatic children from two cohort studies conducted in Mexico City were included. Stratified linear mixed models with random intercepts and random slopes on ozone were used. Potential confounding by ethnicity was assessed. Analyses were conducted under single gene and genotype score approaches.

Results

The change in FEF_25-75 per interquartile range (60 ppb) of ozone in persistent asthmatic children with low vitamin C intake and GSTM1 null was −91.2 ml/s (p = 0.06). Persistent asthmatic children with 4 to 6 risk alleles and low vitamin C intake showed an average decrement in FEF_25-75 of 97.2 ml/s per 60 ppb of ozone (p = 0.03). In contrast in children with 1 to 3 risk alleles, acute effects of ozone on FEF_25-75 did not differ by vitamin C intake.

Conclusions

Our results provide further evidence that asthmatic children predicted to have compromised antioxidant defense by virtue of genetic susceptibility combined with deficient antioxidant intake may be at increased risk of adverse effects of ozone on pulmonary function.

【 授权许可】

   
2013 Moreno-Macías et al.; licensee BioMed Central Ltd.

【 图 表 】

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