Streptococcus pneumoniae colonisation in children and adolescents with asthma: impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine

BMC Infectious Diseases

Research Article

Oscar Mazzina¹  Michele Miraglia del Giudice²  Eugenio Baraldi³  Amelia Licari⁴  Gian Luigi Marseglia⁴  Alessandro Bodini⁵  Claudia Tagliabue⁶  Maria Francesca Patria⁶  Susanna Esposito⁶  Mara Lelii⁶  Nicola Principi⁶  Leonardo Terranova⁶  Valentina Ierardi⁶  Alberto Martelli⁷ 

[1] Allergology Unit, IRCCS Bambino Gesù Hospital, Rome, Italy;Pediatric Clinic, II Naples University, Naples, Italy;Pediatric Clinic, University of Padua, Padua, Italy;Pediatric Clinic, University of Pavia, IRCCS Policlinico “S. Matteo” Foundation, Pavia, Italy;Pediatric Clinic, University of Verona, Verona, Italy;Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122, Milan, Italy;Pediatric Unit, Garbagnate Hospital, Garbagnate, Italy;

关键词: Asthma;    Asthmatic children;    Chronic respiratory disease;    PCV7;    PCV13;    Pneumococcal colonisation;    Pneumococcal conjugate vaccine;    Pulmonary disease;    Streptococcus pneumoniae;   

DOI  :  10.1186/s12879-016-1335-3

 received in 2015-06-14, accepted in 2016-01-06,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe main aim of this study was to evaluate Streptococcus pneumoniae carriage in a group of school-aged children and adolescents with asthma because these results might indicate the theoretical risk of invasive pneumococcal disease (IPD) of such patients and the potential protective efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13).MethodsOropharyngeal samples were obtained from 423 children with documented asthma (300 males, 70.9 %), and tested for the autolysin-A-encoding (lytA) and the wzg (cpsA) gene of S. pneumoniae by means of real-time polymerase chain reaction.ResultsS. pneumoniae was identified in the swabs of 192 subjects (45.4 %): 48.4 % of whom were aged <10 years, 46.9 % aged 10–14 years, and 4.7 % aged ≥15 years (p < 0.001). Carriage was significantly less frequent among the children who had received recent antibiotic therapy (odds ratio [OR 0.41]; 95 % confidence interval [95 % CI] 0.22–0.76). Multivariate analyses showed no association between carriage and vaccination status, with ORs of 1.05 (95 % CI 0.70–1.58) for carriers of any pneumococcal serotype, 1.08 (95 % CI 0.72–1.62) for carriers of any of the serotypes included in 7-valent pneumococcal conjugate vaccine (PCV7), and 0.76 (95 % CI 0.45–1.28) for carriers of any of the six additional serotypes of PCV13. Serotypes 19 F, 4 and 9 V were the most frequently identified serotypes in vaccinated subjects.ConclusionsThese results showed that carriage of S. pneumoniae is relatively common in all school-aged children and adolescents with asthma, regardless of the severity of disease and the administration of PCV7 in the first years of life. This highlights the problem of the duration of the protection against colonisation provided by pneumococcal conjugate vaccine, and the importance of re-colonization by the same pneumococcal serotypes included in the previously used vaccine.

【 授权许可】

CC BY   
© Esposito et al. 2016