Autoinflammatory diseases: a possible cause of thrombosis?

Thrombosis Journal

Raffaele Manna²  Francesco Orlandini¹  Micaela La Regina¹ 

[1] Department of Internal Medicine, Ligurian East Hospital, La Spezia, Italy;Centre of Periodic Fevers – Catholic University of Rome, Rome, Italy

关键词: Myocardial infarction;    Stroke;    Arterial thrombosis;    Venous thromboembolism;    Venous thrombosis;    Periodic fevers;    Pyrinopathies;    Criopyrinopathies;    Familial mediterranean fever;    Autoinflammatory diseases;   

Others  :  1204401
DOI  :  10.1186/s12959-015-0049-x

 received in 2014-10-22, accepted in 2015-03-19,  发布年份 2015

【 摘 要 】

Autoinflammatory diseases are a group of disorders due to acquired or hereditary disfunction of innate immune system and characterized by systemic or localized manifestations. The prototype is Familial Mediterranean Fever, a monogenic hereditary disorder, whose causing gene (MeFV gene) was identified in 1997 and opened the way to a new fascinanting chapter of rheumatology. A growing body of monogenic and poligenic autoinflammatory disorders has been described since then.

Arterial and venous thrombosis is a common medical problem, with significant morbidity and mortality. Strong evidences from basic research and clinical epidemiological studies support the theory that inflammation and thrombosis can be associated.

Because of their recurrent/chronic inflammatory nature, autoinflammatory diseases are a putative cause of thrombotic manifestations. In the present work, we reviewed the available evidences about monogenic autoinflammatory disorders, complicated by thrombotic manifestations.

【 授权许可】

   
2015 La Regina et al. ; licensee BioMed Central.

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