Plant-based vaccines against viruses

Virology Journal

Edward P Rybicki¹ 

[1]Biopharming Research Unit, Department of Molecular & Cell Biology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Private Bag X3, Rondebosch, Cape Town, 7701, South Africa

关键词: ZMapp;    Ebola;    Rabies;    Bluetongue;    Influenza;    HPV;    HCV;    HBV;    HIV;    Monoclonal antibody;    Plant-made antigen;    Biofarming;    Vaccine;    Virus;   

Others  :  1131081
DOI  :  10.1186/s12985-014-0205-0

 received in 2014-08-20, accepted in 2014-11-17,  发布年份 2014

【 摘 要 】

Plant-made or “biofarmed” viral vaccines are some of the earliest products of the technology of plant molecular farming, and remain some of the brightest prospects for the success of this field. Proofs of principle and of efficacy exist for many candidate viral veterinary vaccines; the use of plant-made viral antigens and of monoclonal antibodies for therapy of animal and even human viral disease is also well established. This review explores some of the more prominent recent advances in the biofarming of viral vaccines and therapies, including the recent use of ZMapp for Ebolavirus infection, and explores some possible future applications of the technology.

【 授权许可】

   
2014 Rybicki; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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