Reconstruction of large-size abdominal wall defect using biodegradable poly-p-dioxanone mesh: an experimental canine study

World Journal of Surgical Oncology

Hua Tang²  Xiong Qin¹  Zhifei Xu²  Juxian Sun²  Linyun Wei²  Benbo Lv²  Xinyu Ding²  Kenan Huang² 

[1] Department of Thoracic and Cardiovascular Surgery, First People's Hospital of Shanghai, Shanghai Jiaotong University, Shanghai China;Department of Thoracic and Cardiovascular Surgery, Changzheng Hospital, the Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China

关键词: Reconstruction;    Poly-p-dioxanone;    Mesh;    Marlex;    Large size;    Canine model;    Abdominal wall defect;   

Others  :  820247
DOI  :  10.1186/1477-7819-12-57

 received in 2013-03-04, accepted in 2014-02-19,  发布年份 2014

【 摘 要 】

Background

Reconstruction of large-size abdominal wall defect (AWDs) is a huge challenge faced in current surgical practice. In this study, we aimed to evaluate the effectiveness and safety of biodegradable poly-p-dioxanone (PDO) mesh for reconstructing large-size AWDs in an experimental canine model.

Methods

Eighteen experimental canines were randomly and equally divided into three groups, namely, a PDO group, a Marlex group and a control group (n = 6 each). Following the creation of a 6 cm × 5.5 cm AWD, PDO mesh and Marlex mesh were used to reconstruct the defect in the PDO and Marlex groups, respectively. The defect was closed using relaxation sutures alone in the control group. Animals were killed 24 weeks after surgery, and reconstruction outcomes were evaluated using radiography, histology and biomechanical testing.

Results

All animals except those in the control group survived the experiment. The PDO group showed no wound dehiscence, herniation or infection, whereas the animals in the Marlex group exhibited marked foreign body reactions. The PDO group had less intraabdominal adhesion than the Marlex group. As shown by radiography, histology and biomechanical testing, PDO mesh exhibited complete degradation and favorable biochemical strength at 24 weeks postsurgery.

Conclusions

PDO mesh implantation is an effective, safe treatment modality for reconstructing large-size AWDs.

【 授权许可】

   
2014 Huang et al.; licensee BioMed Central Ltd.

【 图 表 】

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