Reconstruction of large-size abdominal wall defect using biodegradable poly-p-dioxanone mesh: an experimental canine study

World Journal of Surgical Oncology

Research

Linyun Wei¹  Zhifei Xu¹  Xinyu Ding¹  Juxian Sun¹  Hua Tang¹  Kenan Huang¹  Benbo Lv¹  Xiong Qin² 

[1] Department of Thoracic and Cardiovascular Surgery, Changzheng Hospital, the Second Military Medical University, 415 Fengyang Road, 200003, Shanghai, China;Department of Thoracic and Cardiovascular Surgery, First People's Hospital of Shanghai, Shanghai Jiaotong University, Shanghai, China;

关键词: Abdominal wall defect;    Canine model;    Large size;    Marlex;    Mesh;    Poly-p-dioxanone;    Reconstruction;   

DOI  :  10.1186/1477-7819-12-57

 received in 2013-03-04, accepted in 2014-02-19,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundReconstruction of large-size abdominal wall defect (AWDs) is a huge challenge faced in current surgical practice. In this study, we aimed to evaluate the effectiveness and safety of biodegradable poly-p-dioxanone (PDO) mesh for reconstructing large-size AWDs in an experimental canine model.MethodsEighteen experimental canines were randomly and equally divided into three groups, namely, a PDO group, a Marlex group and a control group (n = 6 each). Following the creation of a 6 cm × 5.5 cm AWD, PDO mesh and Marlex mesh were used to reconstruct the defect in the PDO and Marlex groups, respectively. The defect was closed using relaxation sutures alone in the control group. Animals were killed 24 weeks after surgery, and reconstruction outcomes were evaluated using radiography, histology and biomechanical testing.ResultsAll animals except those in the control group survived the experiment. The PDO group showed no wound dehiscence, herniation or infection, whereas the animals in the Marlex group exhibited marked foreign body reactions. The PDO group had less intraabdominal adhesion than the Marlex group. As shown by radiography, histology and biomechanical testing, PDO mesh exhibited complete degradation and favorable biochemical strength at 24 weeks postsurgery.ConclusionsPDO mesh implantation is an effective, safe treatment modality for reconstructing large-size AWDs.

【 授权许可】

Unknown   
© Huang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.