Low-dose splenic irradiation in symptomatic congestive splenomegaly: report of five cases with literature data

Radiation Oncology

Stefan Janssen²  Arne Dettmer¹  Michael Bremer²  Frank Bruns² 

[1] Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany;Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany

关键词: Benign disease;    Radiotherapy;    Symptomatic;    Congestive splenomegaly;    Splenic irradiation;   

Others  :  810479
DOI  :  10.1186/1748-717X-9-86

 received in 2014-01-23, accepted in 2014-03-16,  发布年份 2014

【 摘 要 】

Background

To show effectiveness of low-dose splenic irradiation in symptomatic congestive splenomegaly.

Methods

Five patients were referred to our department for symptomatic congestive splenomegaly within three years. Primary diseases were autoimmune hepatitis with liver cirrhosis (n = 2), cystic fibrosis (n = 1), granulomatous liver disease (n = 1) and Werlhof disease with liver cirrhosis (n = 1). Mean age was 54 years (range: 36–67). Patients received splenic irradiation with a total dose of 3 Gy (single dose: 0.5 Gy). One patient was re-irradiated after long-term failure with the same treatment schedule.

Results

In four patients long term relief of splenic pain could be observed during the follow-up time of median 20 (range: 2–36) months. Four patients showed haematological response after irradiation with an increase of erythrocytes, leucocytes and/or platelets. A slightly decrease in spleen size was found in two patients.

Conclusions

Low-dose splenic irradiation in symptomatic congestive splenomegaly is feasible and perhaps as effective as in lympho-and myeloproliferative malignancies regarding pain relief and haematological response.

【 授权许可】

   
2014 Bruns et al.; licensee BioMed Central Ltd.

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