Helminths and malaria co-infections are associated with elevated serum IgE

Particle and Fibre Toxicology

Daniel Elias²  Fusao Ota⁵  Beyene Moges⁴  Yeshambel Belyhun⁴  Techalew Shimelis⁶  Demise Nigussie⁶  Berhanu Erko³  Mengistu Legesse³  Afework Kassu⁴  Andargachew Mulu¹ 

[1] Institute of Virology, Faculty of Medicine, Leipzig University, Leipzig, Germany;ACE Biosciences, Unsbjergvej 2A, 5220 Odense, SOE, Denmark;Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia;Department of Microbiology, College of Medicine, University of Gondar, Gondar, Ethiopia;Department of Preventive Environment and Nutrition, Graduate School of Nutrition and Bioscience, Institute of Health Biosciences, The University of Tokushima, Tokushima 770-8503, Japan;School of Medical Laboratory Technology, College of Health Sciences, Hawasa University, Hawasa, Ethiopia

关键词: Ethiopia;    IgE;    Th2;    Malaria;    Helminths;   

Others  :  806330
DOI  :  10.1186/1756-3305-7-240

 received in 2014-04-23, accepted in 2014-05-19,  发布年份 2014

【 摘 要 】

Background

Both helminth and malaria infections result in a highly polarized immune response characterized by IgE production. This study aimed to investigate the total serum IgE profile in vivo as a measure of Th2 immune response in malaria patients with and without helminth co-infection.

Methods

A cross sectional observational study composed of microscopically confirmed malaria positive (N = 197) and malaria negative (N = 216) apparently healthy controls with and without helminth infection was conducted at Wondo Genet Health Center, Southern Ethiopia. A pre-designed structured format was utilized to collect socio-demographic and clinical data of the subjects. Detection and quantification of helminths, malaria parasites and determination of serum IgE levels were carried out following standard procedures.

Results

Irrespective of helminth infection, individuals infected by malaria showed significantly high levels of serum IgE compared with malaria free apparently healthy controls (with and without helminth infections). Moreover, malaria patients co-infected with intestinal helminths showed high level of serum IgE compared with those malaria patients without intestinal helminths (2198 IU/ml versus 1668 IU/ml). A strong statistically significant association was observed between malaria parasite density and elevated serum IgE levels (2047 IU/ml versus 1778 IU/ml; P = 0.001) with high and low parasitaemia (parasite density >50,000 parasite/μl of blood), respectively. Likewise, helminth egg loads were significantly associated with elevated serum IgE levels (P = 0.003).

Conclusions

The elevated serum IgE response in malaria patients irrespective of helminth infection and its correlation with malaria parasite density and helminth egg intensity support that malaria infection is also a strong driver of IgE production as compared to helminths.

【 授权许可】

   
2014 Mulu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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