Effect of deworming on Th2 immune response during HIV-helminths co-infection

Journal of Translational Medicine

Sisay Yifru¹  Afework Kassu³  Fuso Ota⁴  Aschalew Gelaw³  Belay Anagaw³  Andargachew Mulu² 

[1] Department of Pediatrics and Child Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia;Institute of Virology, Leipzig University, Johannisallee 30, Leipzig, 04103, Germany;Department of Microbiology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia;Department of Preventive Environment and Nutrition, Graduate School of Nutrition and Bioscience, Institute of Health Biosciences, The University of Tokushima, Tokushima 770-8503, Japan

关键词: Ethiopia;    IgE;    Th2;    Deworming;    ART;    Helminths;   

Others  :  1221444
DOI  :  10.1186/s12967-015-0600-3

 received in 2014-12-10, accepted in 2015-07-08,  发布年份 2015

【 摘 要 】

Background

Helminths infections have been suggested to worsen the outcome of HIV infection by polarizing the immune response towards Th2. The purpose of this study is to determine the activity of Th2 immune response by measuring total serum IgE level during symptomatic and asymptomatic HIV infection with and without helminths co-infection and to define the role of deworming and/or ART on kinetics of serum IgE.

Methods

This prospective comparative study was conducted among symptomatic HIV-1 infected adults, treatment naïve asymptomatic HIV positive individuals and HIV negative apparently healthy controls with and without helminths co-infection. Detection and quantification of helminths and determination of serum IgE level, CD4 ⁺ , and CD8 ⁺T cell count were done at baseline and 12 weeks after ART and/or deworming.

Results

HIV patients co-infected with helminths showed a high level of serum IgE compared to HIV patients without helminths co-infection (1,688 [IQR 721–2,473] versus 1,221 [IQR 618–2,289] IU/ml; P = 0.022). This difference was also markedly observed between symptomatic HIV infected patients after with and without helminths infection (1,690 [IQR 1,116–2,491] versus 1,252 [703–2,251] IU/ml; P = 0.047). A significant decline in serum IgE level was observed 12 weeks after deworming and ART of symptomatic HIV infected patients with (1,487 versus 992, P = 0.002) and without (1,233 versus 976 IU/ml, P = 0.093) helminths co-infection. However, there was no significant decrease in serum IgE level among asymptomatic HIV infected individuals (1,183 versus 1,097 IU/ml, P = 0.13) and apparently health controls (666 IU/ml versus 571, P = 0.09) without helminths co-infection 12 weeks after deworming.

Conclusions

The significant decline of serum IgE level 12 weeks after deworming of both symptomatic and asymptomatic patients indicate a tendency to down-regulate the Th2 immune response and is additional supportive evidence that deworming positively impacts HIV/AIDS diseases progression. Thus, deworming should be integrated with ART program in helminths endemic areas of tropical countries.

【 授权许可】

   
2015 Mulu et al.

【 图 表 】

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