Eradication of breast cancer with bone metastasis by autologous formalin-fixed tumor vaccine (AFTV) combined with palliative radiation therapy and adjuvant chemotherapy: a case report

World Journal of Surgical Oncology

Tadao Ohno¹  Fumito Kuranishi² 

[1] Advanced Research Institute for Science and Engineering, Waseda University, Shinjuku-ku, Tokyo, 169-8555, Japan;Department of Surgery, Innoshima-Ishikai Hospital, Innoshima, Onomichi, Hiroshima, 722-2211, Japan

关键词: Eradication;    Bone metastasis;    Mammary carcinoma;    Tumor vaccine;   

Others  :  823893
DOI  :  10.1186/1477-7819-11-127

 received in 2012-10-23, accepted in 2013-05-09,  发布年份 2013

【 摘 要 】

Skeletal metastasis of breast carcinoma is refractory to intensive chemo-radiation therapy and therefore is assumed impossible to cure. Here, we report an advanced case of breast cancer with vertebra-Th7 metastasis that showed complete response to combined treatments with formalin-fixed autologous tumor vaccine (AFTV), palliative radiation therapy with 36 Gy, and adjuvant chemotherapy with standardized CEF (cyclophosphamide, epirubicin, and 5FU), zoledronic acid, and aromatase inhibitors following mastectomy for the breast tumor. The patient has been disease-free for more than 4 years after the mammary surgery and remains well with no evidence of metastasis or local recurrence. Thus, a combination of AFTV, palliative radiation therapy, and adjuvant chemotherapy may be an effective treatment for this devastating disease.

【 授权许可】

   
2013 Kuranishi and Ohno; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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