The gene encoding interleukin-13: a susceptibility locus for asthma and related traits

Respiratory Research

Marsha Wills-Karp¹ 

[1] Johns Hopkins University, Baltimore, Maryland, USA

关键词: interleukin-13;    interleukin-4 receptor;    genetics;    atopy;    asthma;   

Others  :  1227491
DOI  :  10.1186/rr7

 received in 2000-04-14, accepted in 2000-07-03,  发布年份 2000

【 摘 要 】

Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discuss several recent studies that have identified polymorphisms in the gene encoding interleukin-13. The consistent genetic associations of interleukin-13 with asthma and related traits across diverse ethnic populations in these studies provides strong support for the candidacy of this cytokine as a susceptibility locus for asthma and atopy on chromosome 5q31.

【 授权许可】

   
2000 Current Science Ltd

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