Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer

International Journal of Molecular Sciences

Xujun Song¹  Jingwei Shi¹  Benno Traub¹  Marko Kornmann¹ 

[1] Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany;

关键词: interleukin-4;    interleukin-13;    interleukin-4 receptor;    interleukin-13 receptor;    gastrointestinal cancer;   

DOI  :  10.3390/ijms22020727

来源: DOAJ

【 摘 要 】

Interleukin (IL)-4 and -13 are structurally and functionally related cytokines sharing common receptor subunits. They regulate immune responses and, moreover, are involved in the pathogenesis of a variety of human neoplasms. Three different receptors have been described for IL-4, but only IL-4 receptor type II (IL-4Rα/IL-13Rα1) is expressed in solid tumors. While IL-13 can also bind to three different receptors, IL-13 receptor type I (IL-4Rα/IL-13Rα1/IL-13Rα2) and type II (IL-4Rα/IL-13Rα1) are expressed in solid tumors. After receptor binding, IL-4 and IL-13 can mediate tumor cell proliferation, survival, and metastasis in gastric or colon cancer. This review summarizes the results about the role of IL-4/IL-13 and their receptors in gastric and colon cancer.

【 授权许可】

Unknown