The sequence and analysis of a Chinese pig genome

GigaScience

Yutao Du⁵  Songgang Li⁶  Shutang Feng⁸  Jian Wang⁶  Huanming Yang⁶  Lars Bolund⁴  Jun Wang⁷  Yingrui Li⁶  Guojie Zhang⁶  Liangxue Lai²  Shulin Yang⁸  Guangbiao Wang⁶  Kui Li⁸  Juan Wang⁶  Chuxin Liu⁵  Lijie Ren³  Likai Mao⁶  Dingding Fan⁶  Huan Liu⁵  Lan Yang⁶  Zhiqiang Xiong⁶  Xiaoqing Sun⁶  Wei Zhao⁶  Xuanting Jiang⁶  Yuanxin Chen⁶  Yue Feng⁶  Yanfeng Zhang¹  Lijuan Han⁶  Yong Li⁵  Zhiyong Huang⁶  Yulian Mou⁸  Xiaodong Fang⁶ 

[1] State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China;Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangdong, China;Department of Neurology, Shenzhen Second People’s Hospital (First Affiliated Hospital of Shenzhen University), Shenzhen, 518035, China;Department of Biomedicine, Aarhus University, Aarhus C, Denmark;BGI Ark Biotechnology (BAB), Bei Shan Road, Yantian, Shenzhen, 518083, China;BGI-Shenzhen, Bei Shan Road, Yantian, Shenzhen, 518083, China;Department of Biology, University of Copenhagen, Copenhagen, Denmark;Institute of Animal Science (IAS), Chinese Academy of Agriculture Science (CAAS), Beijing, 10094, China

关键词: Animal model;    Endogenous retrovirus;    Transposable element;    Homozygosis;    Genome;    Wuzhishan pig;   

Others  :  861697
DOI  :  10.1186/2047-217X-1-16

 received in 2012-02-20, accepted in 2012-08-08,  发布年份 2012

【 摘 要 】

Background

The pig is an economically important food source, amounting to approximately 40% of all meat consumed worldwide. Pigs also serve as an important model organism because of their similarity to humans at the anatomical, physiological and genetic level, making them very useful for studying a variety of human diseases. A pig strain of particular interest is the miniature pig, specifically the Wuzhishan pig (WZSP), as it has been extensively inbred. Its high level of homozygosity offers increased ease for selective breeding for specific traits and a more straightforward understanding of the genetic changes that underlie its biological characteristics. WZSP also serves as a promising means for applications in surgery, tissue engineering, and xenotransplantation. Here, we report the sequencing and analysis of an inbreeding WZSP genome.

Results

Our results reveal some unique genomic features, including a relatively high level of homozygosity in the diploid genome, an unusual distribution of heterozygosity, an over-representation of tRNA-derived transposable elements, a small amount of porcine endogenous retrovirus, and a lack of type C retroviruses. In addition, we carried out systematic research on gene evolution, together with a detailed investigation of the counterparts of human drug target genes.

Conclusion

Our results provide the opportunity to more clearly define the genomic character of pig, which could enhance our ability to create more useful pig models.

【 授权许可】

   
2012 Fang et al.; licensee BioMed Central Ltd.

【 图 表 】

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