Response to commentary on a trial comparing krill oil versus fish oil

Lipids in Health and Disease

Peter JH Jones¹  Sigalit Zchut²  Inbal Eyal²  Vanu R Ramprasath¹ 

[1] Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada;Enzymotec Ltd., P.O.B 6 Migdal HaEmeq, Israel

关键词: Fatty acids;    Fish oil;    Krill oil;   

Others  :  811703
DOI  :  10.1186/1476-511X-13-17

 received in 2014-01-08, accepted in 2014-01-08,  发布年份 2014

【 摘 要 】

Nichols et al. (Lipids Health Dis13:2, 2014) raised concern about the higher n-6 concentration in fish oil used in our recent study which is different from typical commercial fish oils (Ramprasath et al. Lipids Health Dis12:178, 2013). The aim of our study was to compare the effect of consumption of similar amount of n-3 PUFA from krill and fish oil with placebo on plasma and RBC fatty acids. As the concentration of n-3 PUFA in the fish oil utilised was higher than that in krill oil, we deemed it important to keep consistent the concentration of n-3 PUFA and volumes to be administered to participants between krill versus fish oils. As such, the fish oil used in the study was diluted with corn oil. Although the n-6 PUFA concentration in fish oil was higher compared to traditionally used fish oil, consumption of the fish oil used in our study actually reduced the total n-6 PUFA in plasma and RBC to a similar extent as did krill oil. Overall, our conclusion was that the increases in plasma and RBC concentrations of EPA and DHA along with improvement in the omega-3 index observed with consumption of krill oil compared with fish oil are due to differences in absorption and bioavailability based on the structural difference of the two oils rather than their n-6 PUFA content.

【 授权许可】

   
2014 Ramprasath et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Ramprasath VR, Eyal I, Zchut S, Jones PJ: Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. Lipids Health Dis 2013, 12:178. BioMed Central Full Text
• [2]Nichols PD, Kitessa SM, Abeywardena M: Commentary on a trial comparing krill oil versus fish oil. Lipids Health Dis 2014, 13:2. BioMed Central Full Text
• [3]Simopoulos AP: Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain. Mol Neurobiol 2011, 44:203-215.
• [4]Alanna M, Joseph G, Linda C: What we eat in America, NHANES 2001–2002: Usual nutrient intakes from food compared to dietary intakes. U.S. Department of Agriculture, Agricultural Research Service; 2005.
• [5]Ulven SM, Kirkhus B, Lamglait A, Basu S, Elind E, Haider T, Berge K, Vik H, Pedersen JI: Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. Lipids 2011, 46:37-46.