Chronic vagus nerve stimulation improves left ventricular function in a canine model of chronic mitral regurgitation

Journal of Translational Medicine

Shu Zhang²  Lepeng Zeng¹  Xiaohong Zhou¹  Jun Yu²  Min Tang²  Haiwen Yu² 

[1] Cardiac Rhythm Disease Management, Chinese Branch of Medtronic Inc., Shanghai, China;State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, People¿s Republic of China

关键词: Heart failure;    Mitral valve insufficiency;    Vagus nerve stimulation;    Autonomic nervous system;   

Others  :  1147360
DOI  :  10.1186/s12967-014-0302-2

 received in 2014-05-04, accepted in 2014-10-21,  发布年份 2014

【 摘 要 】

Background

Autonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, contributes to the progression of heart failure (HF). We hypothesized that chronic vagus nerve stimulation (VNS) could prevent left ventricular (LV) remodeling and dysfunction in a canine HF model induced by chronic mitral regurgitation (MR).

Methods and results

After the MR inducing procedure, 12 survived canines were randomly divided into the control (n?=?6) and the VNS (n?=?6) groups. At month 2, a VNS stimulator system was implanted in all canines. From month 3 to month 6, VNS therapy was applied in the VNS group but not in the control group. At month 6, compared with the control group, the canines in VNS group had significantly higher cardiac output (2.3?±?0.3 versus 2.9?±?0.4 L/min, P?

Conclusions

Chronic VNS therapy may ameliorate MR-induced LV contractile dysfunction and improve the expression of biomarkers, but has less effect in improving LV chamber remodeling.

【 授权许可】

   
2014 Yu et al.; licensee BioMed Central Ltd.

【 图 表 】

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