Solitary uterine metastasis of invasive lobular carcinoma after adjuvant endocrine therapy: a case report

Journal of Medical Case Reports

Kosuke Yoshinaga⁴  Hiroyoshi Suzuki¹  Junko Sakurada¹  Kozo Akagi⁴  Nobuko Ishigaki⁴  Rui Matsuura⁴  Saori Igeta⁴  Hiromitsu Makino⁴  Takako Kudo⁴  Atsushi Hayasaka³  Takashi Shima⁴  Hideki Iwahashi²  Masafumi Toyoshima⁴ 

[1] Department of Pathology, Sendai Medical Center, National Hospital Organization, Sendai, Japan;Department of Obstetrics and Gynecology, Self-Defense Force Sendai Hospital, Sendai, Japan;Department of Obstetrics and Gynecology, Sendai City Hospital, Sendai, Japan;Department of Obstetrics and Gynecology, Sendai Medical Center, National Hospital Organization, 2-8-8, Miyagino, Miyagino-ku, Sendai 983-8520, Miyagi, Japan

关键词: Isolated uterine metastasis;    Invasive lobular carcinoma;    Immunohistochemistry;    Breast cancer;    Anastrozole;   

Others  :  1145526
DOI  :  10.1186/s13256-014-0511-6

 received in 2014-11-25, accepted in 2014-12-30,  发布年份 2015

【 摘 要 】

Introduction

Solitary uterine metastases from extragenital cancers are very rare. Breast cancer is the most frequent primary site of metastasis to the uterine corpus, with invasive lobular carcinoma more likely to spread to gynecologic organs than invasive ductal carcinoma.

Case presentation

A 62-year-old postmenopausal Japanese woman was diagnosed with uterine leiomyomata more than 20 years ago and had been managed conservatively until menopause. Seven years prior to her presentation, she was diagnosed with breast cancer and underwent a partial resection of her right breast for stage IIA invasive lobular carcinoma. She underwent adjuvant chemotherapy, radiotherapy, and five years of anastrozole hormonal therapy. She presented with a growing uterine mass. Her tumor marker levels were markedly increased over the course of her follow-up, but a systemic examination revealed only a solitary uterine tumor. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. A histopathological examination, including detailed immunohistochemistry, confirmed metastatic invasive lobular carcinoma, infiltrating both her uterine myometrium and fibroid tissue.

Conclusion

We report a very rare metastatic pattern of invasive lobular carcinoma and demonstrate that gross cystic disease fluid protein-15 and mammaglobin are useful in the diagnosis of metastatic breast cancer.

【 授权许可】

   
2015 Toyoshima et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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