The role of immunotherapy in solid tumors: report from the Campania Society of Oncology Immunotherapy (SCITO) meeting, Naples 2014

Journal of Translational Medicine

Vincenzo Montesarchio⁹  Sandro Pignata^1,11  Francesco Perrone³  Stefano Pepe⁵  Giovannella Palmieri^1,12  Alessandro Morabito^1,10  Giovanni Pietro Ianniello⁷  Michele De Laurentis⁴  Bruno Daniele¹  Giacomo Cartenì⁸  Raffaele Addeo⁶  Paolo A Ascierto² 

[1] Department of Oncology, A.O. ¿G. Rummo¿, Benevento, Italy;Unit of Melanoma, Cancer Immunotherapy and Innovative Therapies, Istituto Nazionale Tumori Fondazione ¿G. Pascale¿, Via Mariano Semmola, Naples, 80131, Italy;Unità Sperimentazioni Cliniche, Istituto Nazionale Tumori Fondazione ¿G. Pascale¿, Napoli, Italy;Unità Oncologia Medica Senologica, Istituto Nazionale Tumori Fondazione ¿G. Pascale¿, Naples, Italy;Dipartimento di Medicina e Chirurgia, A.O.U. ¿San Giovanni di Dio e Ruggi d¿Aragona¿, University of Salerno, Salerno, Italy;Unit of Oncology, Ospedale ¿San Giovanni di Dio¿, Frattamaggiore, NA, Italy;Department of Oncology, A.O.R.N. ¿S. Anna e S. Sebastiano¿, Caserta, Italy;Unit of Medical Oncology, Dipartimento di Oncopneumoematologia, A.O.R.N. ¿A. Cardarelli¿, Naples, Italy;Unit of Oncology, A.O.R.N. dei COLLI ¿Ospedali Monaldi-Cotugno-CTO¿, Naples, Italy;Unità Oncologia Medica Toraco-Polmonare, Istituto Nazionale Tumori Fondazione ¿G. Pascale¿, Naples, Italy;Dipartimento di Oncologia Uroginecologica, Istituto Nazionale Tumori Fondazione ¿G. Pascale¿, Naples, Italy;Department of Molecular and Clinical Endocrinology and Oncology, University ¿Federico II¿, Naples, Italy

关键词: Solid tumors;    Antigen-specific vaccines;    Cellular vaccine;    Checkpoint inhibitors;    Immunotherapy;   

Others  :  1147525
DOI  :  10.1186/s12967-014-0291-1

 received in 2014-09-07, accepted in 2014-10-08,  发布年份 2014

【 摘 要 】

The therapeutic approach to advanced or metastatic solid tumors, either with chemotherapy or targeted therapies, is mainly palliative. Resistance to chemotherapy occurs very frequently and is one of the most important reasons for disease progression. Immunotherapy has the potential to mount an ongoing, dynamic immune response that can kill tumor cells for an extended time after the conventional therapy has been administered. Such a long-lasting response is potentially able to completely eradicate tumor cells, rather than producing only a temporary killing of cells. The most promising immune-based treatments are monoclonal antibodies that act as checkpoint inhibitors (e.g. ipilimumab and nivolumab), adoptive cell therapy (e.g. T-cells expressing chimeric antigen receptors) and vaccines (e.g. sipuleucel-T). Ipilimumab is currently approved for the treatment of metastatic melanoma and sipuleucel-T is approved for advanced prostate cancer. There is great interest in immunotherapy in other solid tumors, potentially used alone or in a multimodal fashion with chemotherapy and/or biological drugs. In this paper, we review recent advances in immuno-oncology in solid malignancies (except melanoma) as were discussed at the inaugural meeting of the Campania Society of Oncology Immunotherapy (SCITO).

【 授权许可】

   
2014 Ascierto et al.; licensee BioMed Central Ltd.

【 图 表 】

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