Stress-induced molecules MICA as potential target for radioimmunotherapy of cancer

1st International Symposium 'Physics, Engineering and Technologies for Bio-Medicine'

医药卫生;物理学;工业技术

Abakushina, E.V.^1,2 ; Anokhin, Yu.N.^2 ; Abakushin, D.N.^3 ; Kaprin, A.D.^4

A Tsyb Medical Radiological Research Centre - Branch, National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, 4 Koroleva, Obninsk

249036, Russia^1

National Research Nuclear University, MEPhI, 31 Kashirskoe shosse, Moscow

115409, Russia^2

LLC Clinic No 1, 6A Aksenova, Obninsk

249039, Russia^3

National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, 10 Zhukova, Obninsk

249031, Russia^4

关键词: Cancer cells;    Cancer patients;    Potential targets;    Radioimmunotherapy;    Solid tumors;    Stress-induced;    Therapeutic radionuclides;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/784/1/012001/pdf
DOI  :  10.1088/1742-6596/784/1/012001

来源: IOP

【 摘 要 】

Improving the treatment of cancer, increasing their effectiveness and safety is the main objective in the medicine. Molecular nuclear medicine plays an important role in the therapy of cancer. Radioimmunotherapy (RIT) involves the use of antibodies conjugated with therapeutic radionuclides. More often for RIT use the radiolabeled monoclonal antibodies against tumor-associated antigens. Encouraging results have been achieved with this technology in the management of hematologic malignancies. On the contrary, solid tumors have been less responsive. Despite these encouraging results, new potential target for radioimmunodetection and RIT should be found. It was found to increase the level of tumor-associated molecules MICA in the serum of cancer patients. Use of anti-MICA monoclonal antibodies capable a specifically attach to cancer cell via NKG2D ligands and destroy it, is a very promising direction, both therapeutic and diagnostic standpoint.