Meta-analyses between 18 candidate genetic markers and overweight/obesity

Diagnostic Pathology

Shiwei Duan⁴  Yifeng Mai²  Dao Wen Wang¹  Meng Ye²  Qiong Liu⁴  Shizhong Bu⁴  Leiting Xu⁴  Qinwen Wang⁴  Fei Chen³  Qingxiao Hong³  Huadan Ye³  Linlin Tang³ 

[1] Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;The Affiliated Hospital, Ningbo University, 315000 Ningbo, Zhejiang, China;Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 315211 Ningbo, Zhejiang, China;Diabetes Center, School of Medicine, Ningbo University, Ningbo 315211, Zhejiang, China

关键词: Meta-analysis;    Obesity;    Overweight;    Polymorphism;    FAIM2;    SH2B1;   

Others  :  802451
DOI  :  10.1186/1746-1596-9-56

 received in 2014-01-02, accepted in 2014-03-04,  发布年份 2014

【 摘 要 】

Aims

The goal of our study is to investigate the associations between 18 candidate genetic markers and overweight/obesity.

Methods

A total of 72 eligible articles were retrieved from literature databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Meta-analyses of 18 genetic markers among 56,738 controls and 48,148 overweight/obese persons were done by Review Manager 5.0.

Results

Our results showed that SH2B1 rs7498665 polymorphism was significantly associated with the risk of overweight/obesity (overall odds ratio (OR) = 1.21, 95% confidence interval (CI) = 1.09-1.34, P = 0.0004). Increased risk of overweight/obesity was also observed in FAIM2 rs7138803 polymorphism (overall OR = 1.11, 95% CI = 1.01-1.22, P = 0.04).

Conclusion

Our meta-analyses have shown the important role of 2 polymorphisms (SH2B1 rs7498665 and FAIM2 rs7138803) in the development of overweight/obesity. This study highlighted the importance of above two candidate genes (SH2B1 and FAIM2) in the risk of overweight/obesity.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2785487401176182 webcite.

【 授权许可】

   
2014 Tang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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