A clinical study of canine collagen type III glomerulopathy

BMC Veterinary Research

Johan Høgset Jansen³  Frode Lingaas³  Ragnar Thomassen¹  Anna Vigdís Eggertsdóttir²  Runa Rørtveit³ 

[1] Department of Production Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway;Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway;Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway

关键词: Nephropathy;    Juvenile;    Hereditary;    Glomerulopathy;    Dog;    Collagenofibrotic;    Collagen type III;    Canine;    Animal model;   

Others  :  1119420
DOI  :  10.1186/1746-6148-9-218

 received in 2013-02-27, accepted in 2013-10-04,  发布年份 2013

【 摘 要 】

Background

Collagen type III glomerulopathy (Col3GP), also known as collagenofibrotic glomerulonephropathy, is a rare renal disease with unknown pathogenesis that occurs in animals and humans. We recently described a naturally occurring canine autosomal recessive model of Col3GP, and the aim of the present work was to study the clinical features of canine Col3GP and compare with the human phenotype. In humans two different clinical syndromes with different age at onset (child- or adulthood) have been observed. In children a more aggressive course with familial occurrence is described, characterized by progressively increasing proteinuria, nephrotic syndrome, hypertension and chronic renal failure. A markedly increased serum level of the aminoterminal propeptide of type III procollagen (PIIINP) is considered a useful marker for the disease. Since Col3GP and concurrent hypocomplementemia have been observed in humans, we also aimed to investigate if hypocomplementemia was present in Col3GP affected dogs. A litter consisting of seven puppies, four Col3GP affected and three healthy unaffected, was observed from the day of birth until the affected puppies developed a mild or moderate renal azotemia.

Results

During the period of observation growth retardation, increasing blood pressure, progressive proteinuria, azotemia, hypoalbuminemia, hypercholesterolemia and increased serum PIIINP were observed in all the affected dogs. Hypocomplementemia was not detected. Affected dogs were euthanized between 109 and 144 days of age, and pathological examinations revealed ascites and massive glomerular accumulations of collagen type III, consistent with Col3GP.

Conclusions

Dogs with Col3GP develop juvenile chronic renal failure, preceded by nephrotic syndrome, elevated serum PIIINP and hypertension, thus have similar clinical features as the juvenile Col3GP in humans. Further studies of this naturally occurring canine phenotype may provide more information on the pathogenesis and genetics of Col3GP in both animals and humans.

【 授权许可】

   
2013 Rørtveit et al.; licensee BioMed Central Ltd.

【 图 表 】

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