Career perspective: Victor A. Convertino

Extreme Physiology & Medicine

Victor A. Convertino¹ 

[1] U. S. Army Institute of Surgical Research, 3698 Chambers Pass, Building 3611, JBSA Fort Sam Houston 78234-6315, TX, USA

关键词: Medical monitoring;    Intrathoracic pressure regulation;    Compensatory reserve;    Hemorrhage;    Blood volume;    Lower body negative pressure;    Bed rest;    Space;    Heat acclimation;    Exercise;   

Others  :  1234063
DOI  :  10.1186/s13728-015-0040-y

 received in 2015-10-23, accepted in 2015-11-04,  发布年份 2015

【 摘 要 】

This review focuses on a career of unique opportunities to participate in various areas of research related to extreme physiology and medicine. My experience as a volunteer subject in exercise experiments conducted at NASA included the study of acute and chronic physiological responses and adaptations to exercise in environments of hypoxia, heat stress, and simulated microgravity (bed rest), and eventually to my doctoral work on mechanisms underlying expansion of plasma and blood volume with acute and repeated exercise and heat exposure. My career has taken me to research positions at NASA, the Stanford University School of Medicine, the University of Arizona, and the U.S. Air Force Research Laboratory before assuming my present location at the U.S. Army Institute of Surgical Research. As a result of these multiple experiences across a period of 45 years, I have had opportunities to translate basic research to astronauts, high-performance aircraft pilots, and critically ill patients who are challenged by conditions of extreme physiology and medicine.

【 授权许可】

   
2015 Convertino.

【 图 表 】

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【 参考文献 】

• [1]Convertino VA, Greenleaf JE, Bernauer EM. Role of thermal and exercise factors in the mechanism of hypervolemia. J Appl Physiol. 1980; 48:657-664.
• [2]Convertino VA, Thompson CA, Benjamin BA, Keil LC, Savin WM, Gordon EP, Haskell WL, Schroeder JS, Sandler H. Hemodynamic and ADH responses to central blood volume shifts in cardiac-denervated humans. Clin Physiol. 1990; 10:55-67.
• [3]Convertino VA, Goldwater DJ, Sandler H. Bedrest-induced peak VO 2 reduction associated with age, gender and aerobic capacity. Aviat Space Environ Med. 1986; 57:17-22.
• [4]Kirby CR, Convertino VA. Plasma aldosterone and sweat sodium concentrations after exercise and heat acclimation. J Appl Physiol. 1986; 61:967-970.
• [5]Convertino VA. Blood volume: its adaptation to endurance training. Med Sci Sports Exerc. 1991; 23:1338-1348.
• [6]Senay LC, Mitchell D, Wyndham CH. Acclimatization in a hot humid environment: body fluid adjustments. J Appl Physiol. 1976; 40:786-796.
• [7]McKeever KH, Schurg WA, Convertino VA. Exercise training-induced hypervolemia in Greyhound dogs: role of water intake and renal mechanisms. Am J Physiol. 1985; 248:R422-R425.
• [8]McKeever KH, Schurg WA, Convertino VA. Exercise training-induced hypervolemia in the horse. Med Sci Sports Exerc. 1987; 19:21-27.
• [9]Sather TM, Goldwater DJ, Montgomery LD, Convertino VA. Cardiovascular dynamics associated with tolerance to lower body negative pressure. Aviat Space Environ Med. 1986; 57:413-419.
• [10]Vernikos J, Convertino VA. Advantages and disadvantages of fludrocortisone or saline load in preventing post-spaceflight orthostatic hypotension. Acta Astronautica. 1994; 33:259-266.
• [11]Engelke KA, Doerr DF, Crandall CG, Convertino VA. Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity. Am J Physiol. 1996; 271:R837-R847.
• [12]Hikida RS, Gollnick PD, Dudley GA, Convertino VA, Buchanan P. Structural and metabolic characteristics of human skeletal muscle following 30 days of simulated microgravity. Aviat Space Environ Med. 1989; 60:664-670.
• [13]Convertino VA. Aerobic fitness, endurance training and orthostatic intolerance. Exerc Sport Sci Rev. 1987; 15:223-259.
• [14]Convertino VA. Endurance exercise training: conditions of enhanced hemodynamic responses and tolerance to LBNP. Med Sci Sports Exerc. 1993; 25:705-712.
• [15]Convertino VA, Previc FH, Ludwig DA, Engelken EJ. Effects of vestibular-oculomotor stimulation on responsiveness of the carotid-cardiac baroreflex. Am J Physiol. 1997; 273:R615-R622.
• [16]Convertino VA. Mechanisms of blood pressure regulation that differ in men repeatedly exposed to high G acceleration. Am J Physiol. 2001; 280:R947-R958.
• [17]Wenke JC, Walters TJ, Greydanus DJ, Pusateri AE, Convertino VA. Physiological evaluation of the US Army one-handed tourniquet. Mil Med. 2005; 170:776-781.
• [18]Convertino VA, Ryan KL, Rickards CA, Glorsky SL, Idris AH, Yannopoulos D, Metzger A, Lurie KG. Optimizing the respiratory pump: harnessing inspiratory resistance to treat systemic hypotension. Respir Care. 2011; 56:846-857.
• [19]Convertino VA, Grudic GZ, Mulligan J, Moulton S. Estimation of individual-specific progression to cardiovascular instability using arterial waveforms. J Appl Physiol. 2013; 115:1196-1202.
• [20]Convertino VA, Rickards CA, Ryan KL. Autonomic mechanisms associated with heart rate and vasoconstrictor reserves. Clin Auton Res. 2012; 22:123-130.
• [21]Convertino VA. Blood pressure measurement for accurate assessment of patient status in emergency medical settings. Aviat Space Environ Med. 2012; 83:614-619.
• [22]Moulton SL, Mulligan J, Grudic GZ, Convertino VA. Running on empty? The compensatory reserve index. J Trauma Acute Care Surg. 2013; 75:1053-1059.
• [23]Muniz GW, Wampler DA, Manifold CA, Grudic GZ, Mulligan J, Moulton S, Gerhardt RT, Convertino VA. Promoting early diagnosis of hemodynamic instability during simulated hemorrhage with the use of a real-time decision-assist algorithm. J Trauma Acute Care Surg. 2013; 75:S184-S189.