The ubiquitin-proteasome system in glioma cell cycle control

Cell Division

Christos N Papandreou²  Ioannis A Voutsadakis¹  Panagiotis J Vlachostergios² 

[1] Centre Pluridisciplinaire d’ Oncologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, Larissa, 41110, Greece

关键词: Cell cycle;    Ubiquitin;    Proteasome inhibitors;    Glioma;    Ubiquitin-proteasome system;   

Others  :  791157
DOI  :  10.1186/1747-1028-7-18

 received in 2012-06-25, accepted in 2012-07-04,  发布年份 2012

【 摘 要 】

A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors. The ubiquitin-proteasome system (UPS) constitutes a universal protein degradation pathway, essential for the consistent recycling of a plethora of proteins with distinct structural and functional roles within the cell, including cell cycle regulation. High grade tumors, such as glioblastomas have an inherent potential of escaping cell cycle control mechanisms and are often refractory to conventional treatment. Here, we review the association of UPS with several UPS-targeted proteins and pathways involved in regulation of the cell cycle in malignant gliomas, and discuss the potential role of UPS inhibitors in reinstitution of cell cycle control.

【 授权许可】

   
2012 Vlachostergios et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1 .

Figure 2 .

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